Verify Vinblastine

Drug JSON

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{
  "slug": "vinblastine",
  "nameEn": "Vinblastine",
  "nameTh": "วินบลาสทีน",
  "class": "Antineoplastic — vinca alkaloid (mitotic inhibitor)",
  "mechanism": "vinca alkaloid จับ tubulin ยับยั้งการสร้าง mitotic spindle หยุดเซลล์ที่ระยะ metaphase; เป็นหลักของโปรโตคอล mast cell tumor — neurotoxic น้อยกว่า vincristine แต่กดไขกระดูกมากกว่า",
  "brandNamesTh": [
    "Velban",
    "Velbe"
  ],
  "indications": [
    {
      "text": "mast cell tumor (เกรดสูง/แพร่กระจาย คู่ prednisolone หรือ toceranib), lymphoma และมะเร็งอื่น ในสุนัข — ยาหลักของโปรโตคอล MCT",
      "cites": [
        "vsso-vinblastine",
        "paper-vinblastine-mct"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยาเคมีบำบัด PPE; ⚠️ vesicant รุนแรง (extravasation = เนื้อตาย — ต้องสาย IV ที่แน่นอน); กดไขกระดูก (neutropenia dose-limiting); ปรับในตับบกพร่อง",
      "cites": [
        "vsso-vinblastine",
        "paper-vinblastine-mct"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก (neutropenia เด่น), GI upset, vesicant injury หากรั่วออกนอกเส้น; neurotoxicity น้อยกว่า vincristine",
      "cites": [
        "paper-vinblastine-mct"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Mast cell tumor (with prednisolone) — specialist",
      "route": "IV",
      "dose": "2 mg/m² IV สัปดาห์ละครั้ง 4 ครั้งแรก แล้วทุก 2 สัปดาห์อีก 4 ครั้ง (โปรโตคอล 12 สัปดาห์) — ⚠️ oncology only, IV แน่นอน",
      "notes": "ตรวจ CBC ก่อนทุกรอบ; MTD ~3.5 mg/m² (พิษสูงขึ้น)",
      "cites": [
        "vsso-vinblastine",
        "paper-vinblastine-mct"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC ก่อนทุกรอบ (neutrophil nadir ~7 วัน); ตรวจตำแหน่งให้ยาว่าไม่รั่ว",
      "cites": [
        "vsso-vinblastine"
      ]
    }
  ],
  "citations": [
    {
      "id": "vsso-vinblastine",
      "type": "guideline",
      "title": "Vinblastine chemotherapy protocol — Veterinary Society of Surgical Oncology",
      "url": "https://www.vsso.org/chemotherapy-protocols",
      "year": 2024,
      "note": "VSSO chemotherapy protocol reference.",
      "cid": null
    },
    {
      "id": "paper-vinblastine-mct",
      "type": "paper",
      "title": "Efficacy of Vinblastine for Treatment of Canine Mast Cell Tumors (Rassnick, JVIM 2008)",
      "url": "https://onlinelibrary.wiley.com/doi/10.1111/j.1939-1676.2008.0195.x",
      "year": 2023,
      "note": "Peer-reviewed canine MCT vinblastine study.",
      "cid": null
    },
    {
      "id": "wikipedia-vinblastine",
      "type": "monograph",
      "title": "Vinblastine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Vinblastine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01CA01",
      "name": "Vinblastine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / EMA-FDA labels / VSSO / ACVIM-AAHA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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