Verify Vancomycin

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "vancomycin",
  "nameEn": "Vancomycin",
  "nameTh": "แวนโคไมซิน",
  "class": "Antibiotic — glycopeptide (drug of last resort)",
  "mechanism": "glycopeptide ยับยั้งการสร้างผนังเซลล์แบคทีเรีย gram-positive (จับ D-Ala-D-Ala ของ peptidoglycan); ใช้เป็นยาสำรองสุดท้ายสำหรับเชื้อ gram-positive ดื้อยา (MRSP/MRSA, Enterococcus)",
  "brandNamesTh": [
    "Vancocin"
  ],
  "indications": [
    {
      "text": "ติดเชื้อ gram-positive ดื้อยาหลายขนาน (MRSP, MRSA, vancomycin-susceptible Enterococcus) ที่ไม่มีทางเลือกอื่น ในสุนัขและแมว — ⚠️ ยาสำรองสุดท้าย",
      "cites": [
        "merck-glycopeptide",
        "paper-vancomycin"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ drug of LAST RESORT — ใช้เฉพาะเมื่อ culture/sensitivity ยืนยันไม่มีทางเลือก (กัน vancomycin resistance); พิษไต; ให้ IV ช้า (เร็วเกิด \"red man\" reaction); TDM แนะนำ; ปรับตามไต",
      "cites": [
        "merck-glycopeptide",
        "paper-vancomycin"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "พิษไต, ให้เร็วเกิดความดันต่ำ/ผื่นแดง (red man syndrome), phlebitis; ดื้อยาเป็นความเสี่ยงระดับ public health",
      "cites": [
        "paper-vancomycin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Resistant gram-positive (last resort)",
      "route": "IV",
      "dose": "15 mg/kg IV (infuse ช้า ≥1 ชม.) ทุก 6–8 ชั่วโมง — ⚠️ TDM + ปรับตามไต",
      "cites": [
        "paper-vancomycin"
      ]
    },
    {
      "species": "feline",
      "indication": "Resistant gram-positive (last resort)",
      "route": "IV",
      "dose": "~15–20 mg/kg IV (infuse ช้า ≥1 ชม.) ทุก 12 ชั่วโมง — ⚠️ TDM",
      "cites": [
        "paper-vancomycin"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "therapeutic drug monitoring (trough) + ค่าไต; infuse ช้าเพื่อเลี่ยง red man reaction",
      "cites": [
        "paper-vancomycin"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-glycopeptide",
      "type": "textbook",
      "title": "Glycopeptides Use in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antibacterial-agents/glycopeptides-use-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "paper-vancomycin",
      "type": "paper",
      "title": "Parenterally administered vancomycin in 29 dogs and 7 cats (2003-2017, JVIM)",
      "url": "https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.15357",
      "year": 2023,
      "note": "Peer-reviewed small-animal vancomycin case series.",
      "cid": null
    },
    {
      "id": "wikipedia-vancomycin",
      "type": "monograph",
      "title": "Vancomycin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Vancomycin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J01XA01",
      "name": "Vancomycin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / CURATIVE / Tufts CardioRush / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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