Verify Trilostane

Drug JSON

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{
  "slug": "trilostane",
  "nameEn": "Trilostane",
  "nameTh": "ไตรโลสเทน",
  "class": "Adrenal — steroidogenesis inhibitor (canine Cushing)",
  "mechanism": "ยับยั้งเอนไซม์ 3β-hydroxysteroid dehydrogenase ในต่อมหมวกไต ลดการสร้าง cortisol (และ aldosterone บางส่วน); เป็นยาหลักรักษา hyperadrenocorticism (Cushing) ในสุนัข ออกฤทธิ์ชั่วคราวจึงต้องให้ต่อเนื่อง",
  "brandNamesTh": [
    "Vetoryl"
  ],
  "indications": [
    {
      "text": "รักษา hyperadrenocorticism (Cushing) ในสุนัข ทั้งชนิด pituitary-dependent และ adrenal-dependent; ใช้ในแมวบางกรณี (off-label)",
      "cites": [
        "fda-vetoryl",
        "tvp-trilostane"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามใช้ในสัตว์ที่มีโรคไต/ตับรุนแรง, ตั้งท้อง; ⚠️ เสี่ยง iatrogenic hypoadrenocorticism (Addison) — ทั้งชั่วคราวและถาวร; ให้พร้อมอาหาร",
      "cites": [
        "fda-vetoryl",
        "aaha-endocrine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "เบื่ออาหาร อาเจียน ซึม (อาจเป็นสัญญาณ cortisol ต่ำเกิน); ⚠️ hypoadrenocortical crisis (อ่อนแรง ช็อก electrolyte ผิดปกติ) ที่อาจถึงชีวิต; adrenal necrosis พบน้อย",
      "cites": [
        "fda-vetoryl",
        "tvp-trilostane"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Hyperadrenocorticism (Cushing)",
      "route": "PO",
      "dose": "เริ่ม ~1–2 mg/kg PO วันละครั้ง (FDA label 2.2–6.7 mg/kg/วัน) หลายคนเริ่มต่ำ ~1 mg/kg ทุก 12 ชม.; ปรับตาม ACTH stim/cortisol",
      "notes": "ให้พร้อมอาหาร; ปรับขนาดตามผลตรวจ ห้ามปรับโดยไม่ติดตาม",
      "cites": [
        "fda-vetoryl",
        "tvp-trilostane"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ติดตามด้วย ACTH stimulation test หรือ pre-pill cortisol ที่ 10–14 วัน, 30 วัน, 90 วัน หลังเริ่ม/ปรับขนาด; เฝ้าระวัง electrolyte และอาการ Addisonian",
      "cites": [
        "aaha-endocrine",
        "tvp-trilostane"
      ]
    }
  ],
  "citations": [
    {
      "id": "fda-vetoryl",
      "type": "package-insert",
      "title": "Vetoryl (trilostane) — FDA-approved veterinary label",
      "year": 2025,
      "url": "https://www.dechra-us.com/management-areas/companion-animals/endocrinology/canine-hyperadrenocorticism/treating-cushings",
      "note": "FDA/EMA-approved veterinary product label. Public regulatory labeling.",
      "cid": null
    },
    {
      "id": "tvp-trilostane",
      "type": "guideline",
      "title": "Trilostane for Dogs with Hyperadrenocorticism — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/pharmacology/trilostane-for-dogs-with-hyperadrenocorticism/",
      "year": 2024,
      "note": "Peer-reviewed veterinary clinical practice journal.",
      "cid": null
    },
    {
      "id": "aaha-endocrine",
      "type": "guideline",
      "title": "2023 AAHA Selected Endocrinopathies of Dogs and Cats Guidelines",
      "url": "https://www.aaha.org/resources/2023-aaha-selected-endocrinopathies-of-dogs-and-cats-guidelines/",
      "year": 2023,
      "note": "AAHA consensus guideline. Authoritative.",
      "cid": null
    },
    {
      "id": "wikipedia-Trilostane",
      "type": "monograph",
      "title": "Trilostane — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Trilostane",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "H02CA01",
      "name": "Trilostane",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / AAHA + ACVIM guidelines / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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