Verify Tranexamic acid

Drug JSON

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{
  "slug": "tranexamic-acid",
  "nameEn": "Tranexamic acid",
  "nameTh": "ทรานเอกซามิก แอซิด",
  "class": "Hematology — antifibrinolytic (hemostatic)",
  "mechanism": "lysine analogue สังเคราะห์ — จับ lysine-binding site ของ plasminogen แบบ reversible ป้องกัน plasmin สลาย fibrin จึงชะลอการสลายลิ่มเลือดและลดเลือดออก (antifibrinolytic)",
  "brandNamesTh": [
    "Transamin",
    "Cyklokapron"
  ],
  "indications": [
    {
      "text": "ภาวะเลือดออก/เสี่ยงเลือดออก (trauma, ผ่าตัด, hyperfibrinolysis, ภาวะเลือดออกใน IMHA/ITP/angiostrongylosis), และใช้เป็น emetic ในสุนัข-แมว (IV เร็ว)",
      "cites": [
        "veteducation-txa",
        "tvp-antifibrinolytic"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ระวังในภาวะลิ่มเลือดอุดตัน/DIC ระยะ hypercoagulable (อาจส่งเสริมลิ่ม); อาเจียน (โดยเฉพาะ IV bolus เร็ว/ขนาดสูง 20 mg/kg); ใช้นาน/ขนาดสูงเสี่ยง retinal changes; ปรับในไตบกพร่อง",
      "cites": [
        "veteducation-txa",
        "tvp-antifibrinolytic"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "อาเจียน (เด่นเมื่อ IV เร็ว/ขนาดสูง), คลื่นไส้; ใช้นานเสี่ยง retinal change; ลิ่มเลือดในภาวะเสี่ยง",
      "cites": [
        "tvp-antifibrinolytic"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Active hemorrhage / antifibrinolytic",
      "route": "IV",
      "dose": "10–15 mg/kg IV ช้า ๆ ทุก 8 ชั่วโมง จนเลือดหยุด (PO ~15–20 mg/kg ได้)",
      "cites": [
        "veteducation-txa",
        "tvp-antifibrinolytic"
      ]
    },
    {
      "species": "feline",
      "indication": "Active hemorrhage",
      "route": "IV",
      "dose": "10–15 mg/kg IV ช้า ๆ ทุก 8 ชั่วโมง",
      "cites": [
        "tvp-antifibrinolytic"
      ]
    }
  ],
  "citations": [
    {
      "id": "veteducation-txa",
      "type": "guideline",
      "title": "Clinical Use of Tranexamic Acid in the Dog — VetEducation",
      "url": "https://veteducation.com/clinical-use-of-tranexamic-acid-in-the-dog/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "tvp-antifibrinolytic",
      "type": "guideline",
      "title": "Antifibrinolytic Drugs in Small Animal Medicine — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/pharmacology/antifibrinolytic-drugs-in-small-animal-medicine/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-tranexamic_acid",
      "type": "monograph",
      "title": "Tranexamic acid — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Tranexamic_acid",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "B02AA02",
      "name": "Tranexamic acid",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / dvm360 / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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