Verify Torsemide (torasemide)

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "torsemide",
  "nameEn": "Torsemide (torasemide)",
  "nameTh": "ทอร์เซไมด์",
  "class": "Loop diuretic — long-acting (refractory CHF)",
  "mechanism": "ยาขับปัสสาวะกลุ่ม loop diuretic เช่นเดียวกับ furosemide แต่ออกฤทธิ์แรงกว่า ~10 เท่าและนานกว่า มีฤทธิ์ต้าน aldosterone บางส่วน; ใช้ในภาวะ CHF ที่ดื้อต่อ furosemide",
  "brandNamesTh": [
    "Upcard",
    "Demadex"
  ],
  "indications": [
    {
      "text": "ลดภาวะคั่งน้ำใน CHF โดยเฉพาะที่ดื้อต่อ furosemide; การศึกษา CARPODIEM (JVIM) สนับสนุนการใช้ใน degenerative mitral valve disease",
      "cites": [
        "carpodiem",
        "upcard-label"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ฤทธิ์แรงกว่า furosemide มาก — เสี่ยงขาดน้ำ/azotemia/electrolyte สูงกว่า; ระวังในไตบกพร่อง; ห้ามในภาวะปัสสาวะไม่ออก (anuria)",
      "cites": [
        "upcard-label"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ขาดน้ำ, hypokalemia, azotemia (เด่นกว่า furosemide เพราะแรงกว่า); ติดตามค่าไตและ electrolyte ใกล้ชิด",
      "cites": [
        "upcard-label"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "CHF (refractory / DMVD)",
      "route": "PO",
      "dose": "0.1–0.6 mg/kg PO วันละครั้ง (ส่วนใหญ่คงที่ที่ ≤ 0.3 mg/kg/วัน; ราว 1/10–1/20 ของขนาด furosemide)",
      "cites": [
        "carpodiem",
        "upcard-label"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจค่าไตและ electrolyte (โดยเฉพาะ K+) บ่อยกว่าการใช้ furosemide เนื่องจากฤทธิ์แรงและนาน",
      "cites": [
        "upcard-label"
      ]
    }
  ],
  "citations": [
    {
      "id": "carpodiem",
      "type": "paper",
      "title": "Efficacy of oral torasemide in dogs with DMVD and new-onset CHF: the CARPODIEM study",
      "url": "https://onlinelibrary.wiley.com/doi/10.1111/jvim.15864",
      "year": 2024,
      "note": "Peer-reviewed RCT (J Vet Intern Med) supporting torasemide in canine CHF.",
      "cid": null
    },
    {
      "id": "upcard-label",
      "type": "package-insert",
      "title": "Upcard (torasemide) — EMA/veterinary label",
      "year": 2024,
      "url": "https://www.evanspharmacy.com/downloads/1527597556Upcard.pdf",
      "note": "Veterinary diuretic label — canine 0.1–0.6 mg/kg q24h.",
      "cid": null
    },
    {
      "id": "wikipedia-Torasemide",
      "type": "monograph",
      "title": "Torasemide — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Torasemide",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C03CA04",
      "name": "Torasemide",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

[]