Verify Telmisartan

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "telmisartan",
  "nameEn": "Telmisartan",
  "nameTh": "เทลมิซาร์แทน",
  "class": "Cardiovascular — angiotensin II receptor blocker (ARB)",
  "mechanism": "ปิดกั้น angiotensin II type-1 (AT1) receptor โดยตรง ลดการหดตัวของหลอดเลือดและ aldosterone จึงลดความดันและ proteinuria; ทางเลือกแทน ACE inhibitor (block ที่ receptor ไม่ใช่ enzyme)",
  "brandNamesTh": [
    "Semintra",
    "Micardis"
  ],
  "indications": [
    {
      "text": "systemic hypertension และลด proteinuria ในแมวโรคไตเรื้อรัง (Semintra, รับรอง); ใช้ลด proteinuria ในสุนัข CKD; ทางเลือก/เสริม ACE inhibitor",
      "cites": [
        "fda-semintra",
        "merck-arb"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามใช้ในภาวะขาดน้ำ/ความดันต่ำ; ระวัง hyperkalemia (โดยเฉพาะใช้ร่วม spironolactone/ACEi); หลีกเลี่ยงในสัตว์ตั้งท้อง",
      "cites": [
        "fda-semintra"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ความดันต่ำ, azotemia, hyperkalemia, GI upset; โดยรวมทนได้ดี",
      "cites": [
        "fda-semintra"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "Hypertension",
      "route": "PO",
      "dose": "1.5 mg/kg PO ทุก 12 ชม. นาน 14 วัน แล้วลดเป็น 2 mg/kg วันละครั้ง",
      "cites": [
        "fda-semintra"
      ]
    },
    {
      "species": "feline",
      "indication": "Proteinuria / CKD",
      "route": "PO",
      "dose": "1 mg/kg PO วันละครั้ง (ลดได้ทีละ 0.5 จนต่ำสุด 0.5 mg/kg หากความดันต่ำ)",
      "cites": [
        "fda-semintra",
        "merck-arb"
      ]
    },
    {
      "species": "canine",
      "indication": "Proteinuric CKD",
      "route": "PO",
      "dose": "1 mg/kg PO วันละครั้ง",
      "cites": [
        "paper-telmisartan-dog"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจความดันโลหิต, ค่าไต, K+ ก่อนและหลังเริ่ม/ปรับขนาด",
      "cites": [
        "merck-arb"
      ]
    }
  ],
  "citations": [
    {
      "id": "fda-semintra",
      "type": "package-insert",
      "title": "Semintra (telmisartan oral solution) — EMA/FDA veterinary label",
      "year": 2025,
      "url": "https://www.petmd.com/pet-medication/telmisartan-semintra-cats",
      "note": "FDA/EMA-approved veterinary product label. Public regulatory labeling.",
      "cid": null
    },
    {
      "id": "merck-arb",
      "type": "textbook",
      "title": "Angiotensin II Receptor Antagonists — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/angiotensin-ii-receptor-antagonists-for-use-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "paper-telmisartan-dog",
      "type": "paper",
      "title": "Telmisartan for proteinuria in dogs with CKD (retrospective study, JVIM)",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8295663/",
      "year": 2023,
      "note": "Peer-reviewed canine proteinuria study — 1 mg/kg q24h.",
      "cid": null
    },
    {
      "id": "wikipedia-telmisartan",
      "type": "monograph",
      "title": "Telmisartan — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Telmisartan",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C09CA07",
      "name": "Telmisartan",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VSSO / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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