Verify Tapentadol

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "tapentadol",
  "nameEn": "Tapentadol",
  "nameTh": "ทาเพนทาดอล",
  "class": "Opioid — atypical (mu agonist + NRI)",
  "mechanism": "opioid ผิดแบบ (atypical) — ออกฤทธิ์คู่: mu-opioid receptor agonist + ยับยั้งการเก็บกลับ noradrenaline (NRI); ลดความปวดทั้งทาง opioid และ descending inhibition (ต่างจาก tramadol ที่อาศัย metabolite)",
  "brandNamesTh": [
    "Nucynta",
    "Palexia"
  ],
  "indications": [
    {
      "text": "ความปวดเฉียบพลัน-ปานกลางถึงรุนแรง (orthopedic, post-op) ในสุนัข — atypical opioid ที่ดูดซึมทางปากได้และไม่ต้องอาศัย metabolite (ต่างจาก tramadol ที่สุนัขสร้าง active metabolite ได้น้อย)",
      "cites": [
        "paper-tapentadol-pk",
        "paper-tapentadol-ortho"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "เป็นยาควบคุม (opioid); ห้ามใช้ร่วม MAOI/serotonergic เกิน (เพราะ NRI — serotonin/adrenergic effects); ครึ่งชีวิตสั้นในสุนัข (~3.5 ชม.) ต้องให้บ่อย; ขนาดที่ศึกษาในสุนัขสูง (10–30 mg/kg) สะท้อน bioavailability ต่ำ; ข้อมูลในแมวจำกัด",
      "cites": [
        "paper-tapentadol-pk"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ซึม, GI upset/คลื่นไส้, กดการหายใจ (opioid); ในสุนัขทนได้ดีในการศึกษา PK",
      "cites": [
        "paper-tapentadol-pk"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Acute / orthopedic pain",
      "route": "PO",
      "dose": "10–30 mg/kg PO (ขนาดในการศึกษาสุนัขสูงเพราะ bioavailability ต่ำ); ครึ่งชีวิตสั้นต้องให้บ่อย — ใช้ภายใต้สัตวแพทย์",
      "cites": [
        "paper-tapentadol-pk",
        "paper-tapentadol-ortho"
      ]
    }
  ],
  "citations": [
    {
      "id": "paper-tapentadol-pk",
      "type": "paper",
      "title": "Pharmacokinetics of atypical opioid tapentadol after oral/IV administration in dogs",
      "url": "https://pubmed.ncbi.nlm.nih.gov/22771148/",
      "year": 2023,
      "note": "Peer-reviewed canine tapentadol PK study.",
      "cid": null
    },
    {
      "id": "paper-tapentadol-ortho",
      "type": "paper",
      "title": "Effectiveness of tapentadol for orthopedic pain in dogs: a pilot study",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7020636/",
      "year": 2023,
      "note": "Peer-reviewed canine tapentadol orthopedic-pain pilot.",
      "cid": null
    },
    {
      "id": "wikipedia-tapentadol",
      "type": "monograph",
      "title": "Tapentadol — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Tapentadol",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N02AX06",
      "name": "Tapentadol",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / dvm360 / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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