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Signatures

0

Version

1

Status

pending

⏳ ยังไม่มี signature

Entry นี้ยังไม่ได้ลงนามโดย key ใดเลย — Phase 0 mirror snapshot ที่รอ Thai translation + faculty signoff. ดูสถานะการ review ที่ หน้า detail

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Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "sucralfate",
  "nameEn": "Sucralfate",
  "nameTh": "ซูคราลเฟต",
  "class": "GI cytoprotective — sucrose-aluminium complex",
  "mechanism": "พอลิเมอร์ sucrose octasulfate ที่จับกับเยื่อบุที่เป็นแผลในภาวะกรด เกิดชั้นเหนียวเคลือบป้องกัน (cytoprotective) ไม่ลดการหลั่งกรดโดยตรง; ออกฤทธิ์เฉพาะที่",
  "brandNamesTh": [
    "Carafate",
    "Antepsin"
  ],
  "indications": [
    {
      "text": "เคลือบป้องกันแผลในทางเดินอาหารและหลอดอาหารอักเสบ (esophagitis) โดยเฉพาะแผลที่เป็นแล้ว; ใช้เสริม PPI (แต่ต้องแยกเวลา)",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "แยกเวลาจาก PPI/H2 blocker และยาอื่นอย่างน้อย 2 ชั่วโมง (ลดการดูดซึมยาอื่น และต้องการกรดเพื่อกระตุ้น); ระวังในสัตว์ไตบกพร่อง (สะสม aluminium)",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ท้องผูก; ลดการดูดซึมยาอื่นที่ให้พร้อมกัน; ไม่ค่อยมีผลทั่วร่างกายเพราะดูดซึมน้อย",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "GI ulcer / esophagitis (mucosal protection)",
      "route": "PO",
      "dose": "สุนัขใหญ่ 0.5–1 g, สุนัขเล็ก 0.25–0.5 g PO ทุก 6–8 ชั่วโมง",
      "notes": "⚠️ ตรวจสอบขนาดในตำราเฉพาะทาง (Plumb's) ก่อนใช้; ให้ห่างจากยาอื่นอย่างน้อย 2 ชั่วโมง",
      "cites": [
        "acvim-gi-protectant",
        "merck-antiulcer"
      ]
    },
    {
      "species": "feline",
      "indication": "GI ulcer / esophagitis",
      "route": "PO",
      "dose": "0.25–0.5 g PO ทุก 8–12 ชั่วโมง",
      "notes": "ให้ห่างจากยาอื่นอย่างน้อย 2 ชั่วโมง",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "citations": [
    {
      "id": "acvim-gi-protectant",
      "type": "guideline",
      "title": "ACVIM Consensus Statement: Rational administration of gastrointestinal protectants to dogs and cats",
      "authors": "Marks SL, et al.",
      "year": 2018,
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6271318/",
      "note": "Peer-reviewed ACVIM consensus (J Vet Intern Med) — PPI/H2/sucralfate evidence + dosing. Authoritative.",
      "cid": null
    },
    {
      "id": "merck-antiulcer",
      "type": "textbook",
      "title": "Antiulcerative Drugs — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/multimedia/table/antiulcerative-drugs",
      "note": "Merck antiulcerative dosing table. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "dailymed-sucralfate",
      "type": "regulatory-database",
      "title": "Sucralfate — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=sucralfate",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "79aead5e3e15c700f39b7e38e86099e8c3136b2b82125ea87794d84eb7c17af4"
    },
    {
      "id": "atc-A02BX02",
      "type": "guideline",
      "title": "ATC A02BX02 — Sucralfate",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=A02BX02&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "f1d57d6177c51090fa520272e7b1abc3a9086d6e019e8aad71b36bf2bbf3f737"
    },
    {
      "id": "pubchem-sucralfate",
      "type": "monograph",
      "title": "Sucralfate — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Sucralfate",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "ee50f7e09236f400a2a4a18f7e334434fd741cc1d9692b96d21bd0a6632e720b"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=sucralfate",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=A02BX02&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Sucralfate",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "79aead5e3e15c700f39b7e38e86099e8c3136b2b82125ea87794d84eb7c17af4",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "f1d57d6177c51090fa520272e7b1abc3a9086d6e019e8aad71b36bf2bbf3f737",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "ee50f7e09236f400a2a4a18f7e334434fd741cc1d9692b96d21bd0a6632e720b",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "A02BX02",
      "name": "Sucralfate",
      "level": 5
    },
    "rxnorm": {
      "cui": "10156",
      "name": "Sucralfate"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 3 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM)). ATC A02BX02 + RxNorm 10156. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — sucralfate mucosal-protectant dosing + 2-hour separation rule verified against ACVIM consensus + Merck antiulcerative table; per-weight gram dose flagged for Plumb's faculty confirmation. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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