Verify Rivaroxaban

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "rivaroxaban",
  "nameEn": "Rivaroxaban",
  "nameTh": "ริวารอกซาบัน",
  "class": "Hematology — direct factor Xa inhibitor (oral anticoagulant)",
  "mechanism": "ยับยั้ง factor Xa โดยตรง (DOAC) ขัดขวางการสร้าง thrombin จึงป้องกันลิ่มเลือด; กินได้ ไม่ต้อง monitor บ่อยเท่า heparin/warfarin",
  "brandNamesTh": [
    "Xarelto"
  ],
  "indications": [
    {
      "text": "ป้องกัน/รักษาลิ่มเลือดอุดตันแดง โดยเฉพาะ feline arterial thromboembolism (ATE) จากโรคหัวใจ (HCM); cardiac chamber thrombus; ใช้เดี่ยวหรือคู่ clopidogrel",
      "cites": [
        "curative-rivaroxaban",
        "paper-rivaroxaban-cat"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ห้าม/ระวังในภาวะเลือดออกหรือเสี่ยงเลือดออก; ไม่มี antidote เฉพาะที่ใช้ง่ายในสัตว์ (andexanet แพง); ปรับในตับ/ไตบกพร่อง; หยุดก่อนผ่าตัด",
      "cites": [
        "curative-rivaroxaban"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "เลือดออก (เด่นสุด — เหงือก ทางเดินอาหาร ปัสสาวะ), GI upset; โดยรวมทนได้ดีในแมว",
      "cites": [
        "paper-rivaroxaban-cat"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "Arterial thromboembolism (ATE)",
      "route": "PO",
      "dose": "0.5–1 mg/kg PO วันละครั้ง (ตาม CURATIVE); ขนาดที่ใช้จริงบ่อย 2.5 mg/ตัว วันละครั้ง",
      "cites": [
        "curative-rivaroxaban",
        "paper-rivaroxaban-cat"
      ]
    },
    {
      "species": "canine",
      "indication": "Thromboembolism",
      "route": "PO",
      "dose": "1–2 mg/kg/วัน PO (แบ่งหรือครั้งเดียว ตามความเสี่ยง)",
      "cites": [
        "curative-rivaroxaban"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "เฝ้าระวังอาการเลือดออกทางคลินิก; anti-Xa (rivaroxaban-calibrated) หรือ TEG/PT ใช้ติดตามได้แต่ไม่บังคับ",
      "cites": [
        "curative-rivaroxaban"
      ]
    }
  ],
  "citations": [
    {
      "id": "curative-rivaroxaban",
      "type": "guideline",
      "title": "CURATIVE consensus on rational use of antithrombotics — direct Xa inhibitors",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6498440/",
      "year": 2024,
      "note": "Veterinary consensus / clinical guideline.",
      "cid": null
    },
    {
      "id": "paper-rivaroxaban-cat",
      "type": "paper",
      "title": "Indications and outcomes of rivaroxaban use in cats (Frontiers Vet Sci)",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12226864/",
      "year": 2023,
      "note": "Peer-reviewed feline rivaroxaban outcome study (66 cats).",
      "cid": null
    },
    {
      "id": "wikipedia-rivaroxaban",
      "type": "monograph",
      "title": "Rivaroxaban — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Rivaroxaban",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "B01AF01",
      "name": "Rivaroxaban",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / CURATIVE / Tufts CardioRush / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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