Verify Pyrimethamine

Drug JSON

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{
  "slug": "pyrimethamine",
  "nameEn": "Pyrimethamine",
  "nameTh": "ไพริเมทามีน",
  "class": "Antiprotozoal — diaminopyrimidine (folate antagonist)",
  "mechanism": "ยับยั้ง dihydrofolate reductase ของโปรโตซัว ขัดขวางการสร้างกรดโฟลิก ใช้รักษา toxoplasmosis, neosporosis และ EPM (มักร่วม sulfonamide แบบ synergistic)",
  "brandNamesTh": [
    "Daraprim"
  ],
  "indications": [
    {
      "text": "โรค Toxoplasma, Neospora ในสุนัข/แมว และ EPM ในม้า — ให้ร่วม sulfonamide (potentiated) และเสริม folinic acid",
      "cites": [
        "dailymed-pyrimethamine",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ กดไขกระดูก (anemia/leukopenia/thrombocytopenia จากการต้านโฟเลต) — เสริม folinic acid (leucovorin) และติดตาม CBC; ห้ามในสัตว์ตั้งท้อง (teratogenic)",
      "cites": [
        "dailymed-pyrimethamine",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก, เบื่ออาหาร/อาเจียน, ซึม; ลดลงได้ด้วยการเสริม folinic acid",
      "cites": [
        "plumbs",
        "wikipedia-Pyrimethamine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Toxoplasmosis / neosporosis (with sulfonamide)",
      "route": "PO",
      "dose": "0.5–1 mg/kg PO วันละครั้ง ร่วม sulfonamide + folinic acid (นานหลายสัปดาห์)",
      "cites": [
        "plumbs",
        "dailymed-pyrimethamine"
      ]
    },
    {
      "species": "equine",
      "indication": "EPM (with sulfadiazine)",
      "route": "PO",
      "dose": "1 mg/kg PO วันละครั้ง ร่วม sulfadiazine นานหลายเดือน",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-P01BD01",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Pyrimethamine (P01BD01)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=P01BD01&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-pyrimethamine",
      "type": "package-insert",
      "title": "Pyrimethamine — DailyMed (FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=pyrimethamine",
      "note": "FDA structured product label (human or veterinary). Authoritative for indications, contraindications, labeled use.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Pyrimethamine",
      "type": "monograph",
      "title": "Pyrimethamine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Pyrimethamine",
      "note": "Tertiary cross-check for class + mechanism + ATC code. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "P01BD01",
      "name": "Pyrimethamine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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