Verify Procainamide

Drug JSON

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{
  "slug": "procainamide",
  "nameEn": "Procainamide",
  "nameTh": "โพรเคนาไมด์",
  "class": "Cardiovascular — class Ia antiarrhythmic",
  "mechanism": "class Ia antiarrhythmic — ปิดกั้น fast sodium channel (ลด conduction velocity) + ยืด refractory period; ใช้คุม ventricular tachyarrhythmia และ supraventricular ที่ผ่าน accessory pathway",
  "brandNamesTh": [
    "Pronestyl",
    "Procanbid"
  ],
  "indications": [
    {
      "text": "ventricular tachyarrhythmia (รวมที่ดื้อ lidocaine), supraventricular tachycardia จาก accessory pathway ในสุนัข — second-line หลัง lidocaine (acute IV) และ sotalol (chronic)",
      "cites": [
        "merck-antiarrhythmic-q3",
        "tufts-procainamide"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ระวัง proarrhythmia + hypotension (ให้ IV ช้า, จำกัด cumulative dose); ห้ามใน complete AV block, torsades/QT ยาว; ปรับในไต/ตับบกพร่อง; ใช้นานอาจเกิด lupus-like syndrome (ในคน)",
      "cites": [
        "merck-antiarrhythmic-q3"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ความดันต่ำ (IV เร็ว), proarrhythmia, GI upset; QT prolongation",
      "cites": [
        "merck-antiarrhythmic-q3"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Ventricular tachyarrhythmia",
      "route": "IV",
      "dose": "IV: 2 mg/kg bolus ช้า ๆ (สูงสุดสะสม 25 mg/kg ใน 10–15 นาที) แล้ว CRI 25–40 mcg/kg/min; PO: 10–20 mg/kg ทุก 6–8 ชั่วโมง",
      "cites": [
        "merck-antiarrhythmic-q3",
        "tufts-procainamide"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ECG ต่อเนื่อง (proarrhythmia/QT) + ความดันโลหิตขณะให้ IV",
      "cites": [
        "merck-antiarrhythmic-q3"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-antiarrhythmic-q3",
      "type": "textbook",
      "title": "Antiarrhythmics for Use in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/antiarrhythmics-for-use-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "tufts-procainamide",
      "type": "guideline",
      "title": "Procainamide — Tufts CardioRush Cardiology Drug Formulary",
      "url": "https://sites.tufts.edu/cardiorush/cardiology-drug-formulary/",
      "year": 2024,
      "note": "Tufts cardiology reference dosing.",
      "cid": null
    },
    {
      "id": "wikipedia-procainamide",
      "type": "monograph",
      "title": "Procainamide — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Procainamide",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C01BA02",
      "name": "Procainamide",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / Tufts CardioRush / FDA labels / VCA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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