Verify Piroxicam

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "piroxicam",
  "nameEn": "Piroxicam",
  "nameTh": "ไพร็อกซิแคม",
  "class": "NSAID — oxicam derivative (notable antitumor use)",
  "mechanism": "ยากลุ่ม NSAID ชนิด oxicam ยับยั้ง COX แบบ nonselective; มี enterohepatic recycling ทำให้ครึ่งชีวิตยาว; นอกจากฤทธิ์ต้านการอักเสบ มีฤทธิ์ต้านมะเร็ง (antitumor) ที่น่าสนใจในสุนัข",
  "brandNamesTh": [
    "Feldene"
  ],
  "indications": [
    {
      "text": "สุนัข — ใช้เป็น adjunct ในมะเร็ง โดยเฉพาะ transitional cell carcinoma (TCC) ของกระเพาะปัสสาวะ ที่มีรายงานช่วยลดขนาดก้อนเนื้องอก; ใช้ด้วยความระวังเนื่องจากขอบเขตความปลอดภัยแคบ",
      "cites": [
        "merck-vet-nsaid"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ความเสี่ยงสูงต่อแผล/เลือดออกในทางเดินอาหาร และ renal papillary necrosis; ห้ามใช้ในโรคไต/ตับและภาวะ GI ulcer; ควรให้ร่วมกับยาปกป้องทางเดินอาหาร (GI protectant)",
      "cites": [
        "merck-vet-nsaid"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "แผลและเลือดออกในทางเดินอาหารเด่นชัด, renal papillary necrosis; enterohepatic recycling ทำให้ครึ่งชีวิตยาวและเพิ่มความเสี่ยงการสะสม",
      "cites": [
        "merck-vet-nsaid"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Antitumor adjunct (TCC) — specialist use",
      "route": "PO",
      "dose": "0.3 mg/kg วันละครั้ง (ขนาดที่รายงานใน TCC)",
      "notes": "⚠️ ขอบเขตความปลอดภัยแคบมาก — Merck ระบุช่วง 0.3-1 mg/kg/วันว่าเริ่มมีพิษ; ต้องให้ร่วม GI protectant และอยู่ภายใต้การดูแลของ oncology; ดู protocol เฉพาะทางและให้ faculty ตรวจสอบก่อนใช้",
      "cites": [
        "merck-vet-nsaid"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-vet-nsaid",
      "type": "textbook",
      "title": "NSAIDs in Animals — MSD/Merck Veterinary Manual (Pharmacology)",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/anti-inflammatory-agents/nonsteroidal-anti-inflammatory-drugs-in-animals",
      "note": "Authoritative veterinary pharmacology reference — verified canine dose, COX selectivity, adverse-effect profile. Copyrighted — cited, not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-piroxicam",
      "type": "monograph",
      "title": "Piroxicam — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Piroxicam",
      "note": "Tertiary cross-check for class, mechanism, brand names. CC BY-SA 4.0. Not sole authority for any clinical claim.",
      "cid": null
    },
    {
      "id": "dailymed-piroxicam",
      "type": "regulatory-database",
      "title": "Piroxicam — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=piroxicam",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "267196ba93c9c22b9cfe125babd8a963cde2babeb36fc8d71059b869a283f7f9"
    },
    {
      "id": "atc-M01AC01",
      "type": "guideline",
      "title": "ATC M01AC01 — Piroxicam",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=M01AC01&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "a609e23b28c1a778560ba4a0db89a50d448b88569cac0fe3762a3a07763d5fa8"
    },
    {
      "id": "pubchem-piroxicam",
      "type": "monograph",
      "title": "Piroxicam — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Piroxicam",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "d0b0236e95205afcd27d999e137db292346587ab801aff31233fd6988d3b5c22"
    },
    {
      "id": "wsava-pain-2022",
      "type": "guideline",
      "title": "WSAVA Global Pain Council — Guidelines for Recognition, Assessment and Treatment of Pain",
      "year": 2022,
      "url": "https://wsava.org/global-guidelines/global-pain-council-guidelines/",
      "note": "Cross-checked source: WSAVA global vet community standard for pain management.",
      "cid": "4f3dfbc8262369e4ed25263fc5fd4051710cda271692dda3c34ef6bcf96b22aa"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=piroxicam",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=M01AC01&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Piroxicam",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    },
    {
      "id": "wsava-pain",
      "name": "WSAVA Global Pain Council guidelines",
      "url": "https://wsava.org/global-guidelines/global-pain-council-guidelines/",
      "asOfDate": "2026-05-27",
      "license": "Free for educational use with attribution"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "267196ba93c9c22b9cfe125babd8a963cde2babeb36fc8d71059b869a283f7f9",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "a609e23b28c1a778560ba4a0db89a50d448b88569cac0fe3762a3a07763d5fa8",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "d0b0236e95205afcd27d999e137db292346587ab801aff31233fd6988d3b5c22",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "wsava-pain",
      "cid": "4f3dfbc8262369e4ed25263fc5fd4051710cda271692dda3c34ef6bcf96b22aa",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "M01AC01",
      "name": "Piroxicam",
      "level": 5
    },
    "rxnorm": {
      "cui": "8525",
      "name": "Piroxicam"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 4 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WSAVA Global Pain Council guidelines). ATC M01AC01 + RxNorm 8525. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — antitumor (TCC) use + GI/renal toxicity profile verified against Merck Veterinary Manual; Merck frames 0.3-1 mg/kg/day as the toxicity-onset range so the TCC dose is presented with narrow-margin cautions and an explicit faculty/oncology check. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ],
  "interactions": [
    {
      "text": "ห้ามใช้ร่วมกับ NSAID อื่น/corticosteroid (เพิ่มพิษ GI มาก); ระวังยาพิษต่อไตและ anticoagulant",
      "cites": [
        "merck-vet-nsaid"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC, ค่าไต และเฝ้าระวัง melena/อาเจียนเป็นเลือดอย่างใกล้ชิด; ตรวจปัสสาวะติดตามทั้งโรคและภาวะแทรกซ้อนทางไต",
      "cites": [
        "merck-vet-nsaid"
      ]
    }
  ]
}

Public keys used

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