Verify Pimobendan

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "pimobendan",
  "nameEn": "Pimobendan",
  "nameTh": "พิโมเบนแดน",
  "class": "Inodilator — calcium sensitizer + PDE3 inhibitor (veterinary)",
  "mechanism": "ยา inodilator สำหรับสัตว์โดยเฉพาะ ออกฤทธิ์สองทาง: เพิ่มความไวของ myofilament ต่อ calcium (เพิ่มแรงบีบหัวใจโดยไม่เพิ่ม oxygen demand มาก) และยับยั้ง PDE3 (ขยายหลอดเลือด); เพิ่มทั้ง inotropy และลด afterload",
  "brandNamesTh": [
    "Vetmedin",
    "Cardisure",
    "Acardi"
  ],
  "indications": [
    {
      "text": "รักษา congestive heart failure จาก myxomatous mitral valve disease (MMVD) และ dilated cardiomyopathy (DCM) ในสุนัข; การศึกษา QUEST แสดงว่าเหนือกว่า benazepril; ชะลอการเกิด CHF ในระยะ preclinical (EPIC study)",
      "cites": [
        "acvim-dmvd",
        "merck-inotropes"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามใช้ในภาวะที่การเพิ่มแรงบีบหัวใจเป็นอันตราย เช่น hypertrophic cardiomyopathy with outflow obstruction; ใช้ในแมวเป็น off-label",
      "cites": [
        "merck-inotropes"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "โดยรวมทนได้ดี; อาจพบ inappetence, อาเจียน, หรือ arrhythmia เล็กน้อย",
      "cites": [
        "merck-inotropes"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "CHF (MMVD / DCM)",
      "route": "PO",
      "dose": "0.5 mg/kg/วัน แบ่งให้ 2 ครั้ง ห่างกัน 12 ชั่วโมง (ช่วง 0.2–0.6 mg/kg/วัน); ให้ก่อนอาหาร ~1 ชม.",
      "cites": [
        "merck-inotropes",
        "acvim-dmvd"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-inotropes",
      "type": "textbook",
      "title": "Positive Inotropes for Use in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/positive-inotropes-for-use-in-animals",
      "note": "Merck — pimobendan + digoxin dosing, digoxin narrow therapeutic index. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "acvim-dmvd",
      "type": "guideline",
      "title": "ACVIM Consensus: diagnosis + treatment of myxomatous mitral valve disease in dogs",
      "year": 2019,
      "url": "https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.15488",
      "note": "ACVIM consensus (J Vet Intern Med) — CHF therapy quartet (furosemide + pimobendan + ACEi + spironolactone). Authoritative.",
      "cid": null
    },
    {
      "id": "dailymed-pimobendan",
      "type": "regulatory-database",
      "title": "Pimobendan — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=pimobendan",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "efdfc9b283119e1b50020317d118937b4e1110a1f32ab864fe675435a7907327"
    },
    {
      "id": "atc-QC01CE90",
      "type": "guideline",
      "title": "ATC QC01CE90 — Pimobendan (veterinary)",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=QC01CE90&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "eef68155e0bd3a3af1a836805aec06da9325a8ce208ebe55698f74b9ef560e28"
    },
    {
      "id": "pubchem-pimobendan",
      "type": "monograph",
      "title": "Pimobendan — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Pimobendan",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "8c28390fe8adb425a620adbee0fdc9eb4ef3db01d518d9fb64052f5f6c394cc9"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=pimobendan",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=QC01CE90&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Pimobendan",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "efdfc9b283119e1b50020317d118937b4e1110a1f32ab864fe675435a7907327",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "eef68155e0bd3a3af1a836805aec06da9325a8ce208ebe55698f74b9ef560e28",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "8c28390fe8adb425a620adbee0fdc9eb4ef3db01d518d9fb64052f5f6c394cc9",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "QC01CE90",
      "name": "Pimobendan (veterinary)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 3 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM)). ATC QC01CE90 (vet-only, no human RxNorm CUI). Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — pimobendan 0.5 mg/kg/day divided BID (range 0.2–0.6) verified against Merck positive-inotropes + ACVIM DMVD consensus. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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