Verify Pilocarpine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "pilocarpine",
  "nameEn": "Pilocarpine",
  "nameTh": "ไพโลคาร์พีน",
  "class": "Ophthalmology — cholinergic (miotic / neurogenic KCS)",
  "mechanism": "direct-acting muscarinic agonist (parasympathomimetic) — กระตุ้นต่อมน้ำตา/น้ำลายและทำให้รูม่านตาหด (miosis); ใช้กินสำหรับ neurogenic KCS (ตาแห้งจากเส้นประสาท) และหยอดสำหรับต้อหินบางชนิด",
  "brandNamesTh": [
    "Pilocarpine",
    "Isopto Carpine"
  ],
  "indications": [
    {
      "text": "neurogenic keratoconjunctivitis sicca (ตาแห้งจากความผิดปกติของเส้นประสาท — กระตุ้นต่อมน้ำตา), ต้อหินบางชนิด (miosis) ในสุนัข; รูปกินใช้กับ neurogenic KCS",
      "cites": [
        "merck-kcs",
        "vin-kcs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ฤทธิ์ cholinergic แรง — ระวังพิษ (น้ำลายไหล อาเจียน ถ่าย หัวใจเต้นช้า) โดยเฉพาะเมื่อกิน; รูปหยอดระคายเคือง (pH เป็นกรด); titrate เพิ่มทีละหยดจนเริ่มมีอาการพิษเล็กน้อย; ห้ามในหอบหืด/แผล GI",
      "cites": [
        "merck-kcs",
        "vin-kcs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "cholinergic — น้ำลายไหล อาเจียน ท้องเสีย หัวใจเต้นช้า; รูปหยอดแสบตา; antidote = atropine",
      "cites": [
        "vin-kcs"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Neurogenic KCS (oral)",
      "route": "PO",
      "dose": "ยาหยอดตา 1–2% หยดผสมอาหาร 1 หยด/10 kg ทุก 12 ชั่วโมง (เริ่มต่ำ เพิ่มทีละหยดทุก 3 วันจนเริ่มมีอาการพิษเล็กน้อย)",
      "cites": [
        "merck-kcs",
        "vin-kcs"
      ]
    },
    {
      "species": "canine",
      "indication": "Glaucoma / miosis (topical)",
      "route": "topical",
      "dose": "pilocarpine 1–2% หยอดตา ตามที่กำหนด",
      "cites": [
        "merck-kcs"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-kcs",
      "type": "textbook",
      "title": "Keratoconjunctivitis Sicca in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/eye-and-ear/the-cornea/keratoconjunctivitis-sicca-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "vin-kcs",
      "type": "guideline",
      "title": "KCS treatment beyond cyclosporine (oral pilocarpine for neurogenic KCS) — WSAVA/VIN",
      "url": "https://www.vin.com/apputil/content/defaultadv1.aspx?pId=24437&id=9382983",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-pilocarpine",
      "type": "monograph",
      "title": "Pilocarpine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Pilocarpine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "S01EB01",
      "name": "Pilocarpine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VIN / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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