Verify Metoclopramide

Drug JSON

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{
  "slug": "metoclopramide",
  "nameEn": "Metoclopramide",
  "nameTh": "เมโตโคลพราไมด์",
  "class": "Anti-emetic / prokinetic — D2 antagonist + 5-HT4 agonist",
  "mechanism": "ออกฤทธิ์ต้าน dopamine (D2) ที่ CTZ (ต้านอาเจียน) และกระตุ้น 5-HT4 เพิ่มการบีบตัวของกระเพาะและลำไส้ส่วนต้น (prokinetic); ผ่าน blood-brain barrier จึงอาจมีผลทางระบบประสาท",
  "brandNamesTh": [
    "Reglan",
    "Plasil",
    "Maxolon"
  ],
  "indications": [
    {
      "text": "อาเจียนและภาวะกระเพาะบีบตัวช้า (delayed gastric emptying, reflux); ใช้เป็น prokinetic ในภาวะ ileus",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามใช้เมื่อสงสัยลำไส้อุดตันหรือทะลุ (เพิ่มการบีบตัว), สัตว์ชัก หรือ pheochromocytoma",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ผลทางระบบประสาทส่วนกลาง (กระสับกระส่าย, extrapyramidal signs), ง่วงซึม; ลดขนาดในสัตว์ไตบกพร่อง",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Vomiting / prokinetic",
      "route": "PO",
      "dose": "0.2–0.5 mg/kg PO/SC/IV ทุก 8 ชั่วโมง หรือ CRI สูงสุด 1–2 mg/kg/วัน",
      "cites": [
        "acvim-gi-protectant"
      ]
    },
    {
      "species": "feline",
      "indication": "Vomiting / prokinetic",
      "route": "IM",
      "dose": "0.2–0.5 mg/kg ทุก 8 ชั่วโมง",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "citations": [
    {
      "id": "acvim-gi-protectant",
      "type": "guideline",
      "title": "ACVIM Consensus Statement: Rational administration of gastrointestinal protectants to dogs and cats",
      "authors": "Marks SL, et al.",
      "year": 2018,
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6271318/",
      "note": "Peer-reviewed ACVIM consensus (J Vet Intern Med) — PPI/H2/sucralfate evidence + dosing. Authoritative.",
      "cid": null
    },
    {
      "id": "dailymed-metoclopramide",
      "type": "regulatory-database",
      "title": "Metoclopramide — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=metoclopramide",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "c96eb3ba640551ae35eaa32828e0f7cbf1db11183b928a88c9ea14b0791db792"
    },
    {
      "id": "atc-A03FA01",
      "type": "guideline",
      "title": "ATC A03FA01 — Metoclopramide",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=A03FA01&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "d76244e69d74a7d8c4b5ae0a8d0df71487572753c5b7d63672a161501d6a16cf"
    },
    {
      "id": "pubchem-metoclopramide",
      "type": "monograph",
      "title": "Metoclopramide — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Metoclopramide",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "758f4b126fc9974e936938000b07938b8fc8eb5e73a5d6a8d5e1eeaec090c496"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=metoclopramide",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=A03FA01&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Metoclopramide",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "c96eb3ba640551ae35eaa32828e0f7cbf1db11183b928a88c9ea14b0791db792",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "d76244e69d74a7d8c4b5ae0a8d0df71487572753c5b7d63672a161501d6a16cf",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "758f4b126fc9974e936938000b07938b8fc8eb5e73a5d6a8d5e1eeaec090c496",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "A03FA01",
      "name": "Metoclopramide",
      "level": 5
    },
    "rxnorm": {
      "cui": "6857",
      "name": "Metoclopramide"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 3 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM)). ATC A03FA01 + RxNorm 6857. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — dog 0.2–0.5 mg/kg q8h or CRI 1–2 mg/kg/day verified against ACVIM consensus statement. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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