Verify Methylene blue

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "methylene-blue",
  "nameEn": "Methylene blue",
  "nameTh": "เมทิลีนบลู",
  "class": "Antidote — methemoglobinemia reversal",
  "mechanism": "ทำหน้าที่เป็น electron acceptor/donor เร่งการเปลี่ยน methemoglobin (Fe³⁺ ที่จับ O₂ ไม่ได้) กลับเป็น hemoglobin ปกติ (Fe²⁺) ผ่าน NADPH-methemoglobin reductase pathway",
  "brandNamesTh": [
    "Methylene blue",
    "Methylthioninium"
  ],
  "indications": [
    {
      "text": "ยาแก้ภาวะ methemoglobinemia (จากพิษ acetaminophen ในแมว, ยาออกซิไดซ์, สารเคมี); ฟื้นความสามารถในการขนส่งออกซิเจนของเลือด",
      "cites": [
        "stanley-mb",
        "paper-mb-dog"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ในแมวระวังมาก — ขนาดสูง/ซ้ำทำให้เกิด Heinz body hemolytic anemia (แมวไวต่อ oxidative damage); ห้ามในภาวะพร่อง G6PD; ให้ IV ช้า ๆ",
      "cites": [
        "stanley-mb",
        "paper-mb-dog"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ปัสสาวะ/เยื่อเมือกสีน้ำเงิน-เขียว (คาดได้), Heinz body anemia (โดยเฉพาะแมวเมื่อให้ซ้ำ), GI upset",
      "cites": [
        "paper-mb-dog"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Methemoglobinemia",
      "route": "IV",
      "dose": "1 mg/kg IV ช้า ๆ (5–30 นาที); ซ้ำได้ 1 mg/kg ที่ 1 ชม. หากยังมีอาการ",
      "cites": [
        "stanley-mb",
        "paper-mb-dog"
      ]
    },
    {
      "species": "feline",
      "indication": "Methemoglobinemia (extreme caution)",
      "route": "IV",
      "dose": "1 mg/kg IV ช้า ๆ ครั้งเดียว — ⚠️ ระวัง Heinz body anemia, หลีกเลี่ยงการให้ซ้ำ",
      "cites": [
        "stanley-mb"
      ]
    }
  ],
  "citations": [
    {
      "id": "stanley-mb",
      "type": "guideline",
      "title": "Methylene Blue in Canine Methemoglobinemia — clinical case",
      "url": "https://stanleyrx.com/blog/post/patient-case-the-use-of-methylene-blue-in-canine-methemoglobinemia",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "paper-mb-dog",
      "type": "paper",
      "title": "Long-term methylene blue in a dog with hereditary methemoglobinemia (JVIM)",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5697180/",
      "year": 2023,
      "note": "Peer-reviewed canine methemoglobinemia case.",
      "cid": null
    },
    {
      "id": "wikipedia-methylene_blue",
      "type": "monograph",
      "title": "Methylene blue — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Methylene_blue",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "V03AB17",
      "name": "Methylthioninium chloride (methylene blue)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VSSO / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

[]