Verify Methotrexate

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "methotrexate",
  "nameEn": "Methotrexate",
  "nameTh": "เมโทเทรกเซต",
  "class": "Antineoplastic — antimetabolite (folate antagonist)",
  "mechanism": "antimetabolite ยับยั้งเอนไซม์ dihydrofolate reductase ลดการสร้าง folate ที่ใช้สังเคราะห์ DNA (S-phase specific); ใช้ในโปรโตคอล lymphoma หลายยา",
  "brandNamesTh": [
    "Methotrexate",
    "MTX"
  ],
  "indications": [
    {
      "text": "lymphoma ในสุนัข — เป็นองค์ประกอบของโปรโตคอลหลายยา (เช่น COAP, LMP maintenance); ใช้น้อยลงในโปรโตคอลสมัยใหม่",
      "cites": [
        "vsso-methotrexate",
        "wikipedia-methotrexate"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยาเคมีบำบัด PPE; กดไขกระดูก + GI toxicity (โดยเฉพาะท้องเสีย — dose-limiting); ⚠️ antidote = leucovorin (folinic acid); ปรับในไตบกพร่อง (ขับทางไต); หลีกเลี่ยง NSAID ร่วม (ลดการขับ)",
      "cites": [
        "vsso-methotrexate"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก, GI toxicity (ท้องเสีย เยื่อบุอักเสบ), พิษตับ/ไต",
      "cites": [
        "vsso-methotrexate"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Lymphoma (multidrug protocol) — specialist",
      "route": "PO",
      "dose": "2.5 mg/m² PO วันละครั้ง หรือ 0.5–0.8 mg/kg IV ทุก 1–3 สัปดาห์ (ตามโปรโตคอล) — ⚠️ oncology only",
      "notes": "ตรวจ CBC + ค่าไต; leucovorin rescue หาก overdose",
      "cites": [
        "vsso-methotrexate"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC + ค่าไต/ตับ; เฝ้า GI toxicity; leucovorin เป็น antidote",
      "cites": [
        "vsso-methotrexate"
      ]
    }
  ],
  "citations": [
    {
      "id": "vsso-methotrexate",
      "type": "guideline",
      "title": "Methotrexate chemotherapy protocol — Veterinary Society of Surgical Oncology",
      "url": "https://www.vsso.org/chemotherapy-protocols",
      "year": 2024,
      "note": "VSSO chemotherapy protocol reference.",
      "cid": null
    },
    {
      "id": "wikipedia-methotrexate",
      "type": "monograph",
      "title": "Methotrexate — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Methotrexate",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01BA01",
      "name": "Methotrexate",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / FDA labels / dvm360 / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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