Verify Methadone

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "methadone",
  "nameEn": "Methadone",
  "nameTh": "เมทาโดน",
  "class": "Opioid analgesic — pure mu agonist + NMDA antagonist",
  "mechanism": "opioid pure mu agonist ที่มีฤทธิ์ NMDA receptor antagonist ร่วม จึงให้ฤทธิ์ระงับปวดดีและลด central sensitization; ไม่กระตุ้น histamine release (ให้ IV ได้); นิยมเป็น premedication/analgesia",
  "brandNamesTh": [
    "Methadone"
  ],
  "indications": [
    {
      "text": "ระงับปวดปานกลางถึงรุนแรงและ premedication ก่อนวางยาสลบในสุนัขและแมว; ทางเลือกแทน morphine โดยมีข้อดีคือไม่ปล่อย histamine และมีฤทธิ์ NMDA antagonist",
      "cites": [
        "merck-methadone",
        "dvm360-b"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังการกดการหายใจ, หัวใจเต้นช้า; เป็นยาควบคุมพิเศษ (controlled drug); ระวังในตับบกพร่อง",
      "cites": [
        "merck-methadone"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดการหายใจ, หัวใจเต้นช้า, ง่วงซึม, panting; แก้ฤทธิ์ด้วย naloxone",
      "cites": [
        "merck-methadone"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Pain / premedication",
      "route": "IV",
      "dose": "0.1–0.5 mg/kg IV/IM ทุก 4–6 ชั่วโมง",
      "cites": [
        "merck-methadone",
        "dvm360-b"
      ]
    },
    {
      "species": "feline",
      "indication": "Pain / premedication",
      "route": "IM",
      "dose": "0.1–0.3 mg/kg IM/IV ทุก 4–6 ชั่วโมง",
      "cites": [
        "dvm360-b"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-methadone",
      "type": "textbook",
      "title": "Pain Management in Small Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/musculoskeletal-system/lameness-in-small-animals/pain-management-in-small-animals-with-lameness",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "dvm360-b",
      "type": "guideline",
      "title": "Analgesic drugs and sedatives (Proceedings) — dvm360",
      "year": 2024,
      "url": "https://www.dvm360.com/view/analgesic-drugs-and-sedatives-proceedings",
      "note": "Veterinary CE proceedings — opioid dosing. Secondary clinical reference.",
      "cid": null
    },
    {
      "id": "wikipedia-Methadone",
      "type": "monograph",
      "title": "Methadone — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Methadone",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N07BC02",
      "name": "Methadone",
      "level": 5
    },
    "rxnorm": {
      "cui": "6813",
      "name": "Methadone"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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