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Verify Ketamine
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Signatures
0
Version
1
Status
pending
⏳ ยังไม่มี signature
Entry นี้ยังไม่ได้ลงนามโดย key ใดเลย — Phase 0 mirror snapshot ที่รอ Thai translation + faculty signoff. ดูสถานะการ review ที่ หน้า detail
Show the raw inputs (paranoid mode)
Drug JSON
This is exactly what your browser canonicalizes + SHA-256-hashes
{
"slug": "ketamine",
"nameEn": "Ketamine",
"nameTh": "คีตามีน",
"class": "Anesthetic — dissociative (NMDA antagonist)",
"mechanism": "ยาสลบชนิด dissociative ออกฤทธิ์ต้าน NMDA receptor ทำให้แยกการรับรู้ (dissociation) มีฤทธิ์ระงับปวด somatic; มักให้ร่วม benzodiazepine (diazepam/midazolam) เพื่อลดอาการเกร็งกล้ามเนื้อและชัก",
"brandNamesTh": [
"Ketalar",
"Ketamax"
],
"indications": [
{
"text": "นำสลบและคงสภาพสลบในสุนัขและแมว มักใช้ร่วม benzodiazepine หรือ alpha-2 agonist; ให้ฤทธิ์ระงับปวดในขนาด sub-anesthetic (CRI)",
"cites": [
"fda-ketaset",
"lumb-jones-anesthesia"
]
}
],
"contraindications": [
{
"text": "ระวังในสัตว์ที่มีโรคหัวใจ (เพิ่ม heart rate + BP), ชัก, ความดันในกะโหลก/ลูกตาสูง; ในแมวที่ไตบกพร่องต้องระวังเพราะขับทางไต",
"cites": [
"lumb-jones-anesthesia"
]
}
],
"sideEffects": [
{
"text": "เกร็งกล้ามเนื้อและชักหากให้เดี่ยว (จึงให้ร่วม benzodiazepine), น้ำลายไหลมาก, ตาเปิดค้าง, ฟื้นแบบ rough recovery; เพิ่ม HR และความดัน",
"cites": [
"lumb-jones-anesthesia"
]
}
],
"dosages": [
{
"species": "canine",
"indication": "IV induction (with benzodiazepine)",
"route": "IV",
"dose": "Ketamine 5–10 mg/kg IV ร่วมกับ diazepam 0.25 mg/kg IV (หรือ midazolam 0.2–0.4 mg/kg)",
"cites": [
"lumb-jones-anesthesia"
]
},
{
"species": "feline",
"indication": "IV induction (with benzodiazepine)",
"route": "IV",
"dose": "Ketamine 5–10 mg/kg IV ร่วมกับ benzodiazepine",
"cites": [
"lumb-jones-anesthesia"
]
}
],
"citations": [
{
"id": "fda-ketaset",
"type": "package-insert",
"title": "Ketaset (ketamine HCl) — FDA-approved veterinary label",
"year": 2025,
"url": "https://www.drugs.com/vet/ketaset.html",
"note": "FDA veterinary label — dissociative anesthetic. Public FDA labeling.",
"cid": null
},
{
"id": "lumb-jones-anesthesia",
"type": "textbook",
"title": "Lumb & Jones Veterinary Anesthesia and Analgesia (5th ed.) — injectable agents",
"year": 2015,
"url": "https://veteriankey.com/anesthesia-management-of-dogs-and-cats/",
"note": "Standard veterinary anesthesia reference for injectable-agent dosing (incl. extra-label benzodiazepine + phenothiazine use). Cited, not mirrored.",
"cid": null
},
{
"id": "dailymed-ketamine",
"type": "regulatory-database",
"title": "Ketamine — NLM DailyMed (FDA Structured Product Labeling)",
"year": 2025,
"url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=ketamine",
"note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
"cid": "92b1e2f5ba07a0b084381fb166409f68472ac4ed3da37482f369afc32382af96"
},
{
"id": "atc-N01AX03",
"type": "guideline",
"title": "ATC N01AX03 — Ketamine",
"year": 2025,
"url": "https://www.whocc.no/atc_ddd_index/?code=N01AX03&showdescription=no",
"note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
"cid": "b63900d16411418343783dbd31c2d2f4fe4bbcb8ca767563d3f451e322248a20"
},
{
"id": "pubchem-ketamine",
"type": "monograph",
"title": "Ketamine — PubChem search",
"year": 2025,
"url": "https://pubchem.ncbi.nlm.nih.gov/#query=Ketamine",
"note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
"cid": "8c86a058e93a21cf1d2dfd7156d08c679d53cefca8b0fcd7eef44ddcb2b77181"
},
{
"id": "who-eml-22",
"type": "guideline",
"title": "WHO Model List of Essential Medicines (22nd List, 2021)",
"year": 2021,
"url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
"note": "Cross-checked source: drug appears on WHO EML — WHO recognizes its place in basic healthcare.",
"cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb"
},
{
"id": "wsava-anesth-2018",
"type": "guideline",
"title": "WSAVA Anaesthesia and Sedation Guidelines",
"year": 2018,
"url": "https://wsava.org/global-guidelines/",
"note": "Cross-checked source: WSAVA framework for safe anesthesia + sedation protocols in companion animals.",
"cid": "33d00d5e60cef25ef915e1a10bce437a52b208e15173796168c8d8868a2f1090"
}
],
"mirroredFrom": [
{
"id": "dailymed",
"name": "NLM DailyMed",
"url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=ketamine",
"asOfDate": "2026-05-27",
"license": "U.S. Government work — public domain. Attribution recommended."
},
{
"id": "atc",
"name": "WHO ATC Classification",
"url": "https://www.whocc.no/atc_ddd_index/?code=N01AX03&showdescription=no",
"asOfDate": "2026-05-27",
"license": "WHO publication, free for use with attribution"
},
{
"id": "pubchem",
"name": "PubChem (NIH/NLM)",
"url": "https://pubchem.ncbi.nlm.nih.gov/#query=Ketamine",
"asOfDate": "2026-05-27",
"license": "NIH/NLM public domain"
},
{
"id": "who-eml",
"name": "WHO Model List of Essential Medicines (22nd List, 2021)",
"url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
"asOfDate": "2026-05-27",
"license": "CC BY-NC-SA 3.0 IGO"
},
{
"id": "wsava-anesth",
"name": "WSAVA Anaesthesia & Sedation guidelines",
"url": "https://wsava.org/global-guidelines/",
"asOfDate": "2026-05-27",
"license": "Free for educational use with attribution"
}
],
"mirrorCIDs": [
{
"sourceId": "dailymed",
"cid": "92b1e2f5ba07a0b084381fb166409f68472ac4ed3da37482f369afc32382af96",
"capturedAt": "2026-05-27",
"status": "stub"
},
{
"sourceId": "atc",
"cid": "b63900d16411418343783dbd31c2d2f4fe4bbcb8ca767563d3f451e322248a20",
"capturedAt": "2026-05-27",
"status": "stub"
},
{
"sourceId": "pubchem",
"cid": "8c86a058e93a21cf1d2dfd7156d08c679d53cefca8b0fcd7eef44ddcb2b77181",
"capturedAt": "2026-05-27",
"status": "stub"
},
{
"sourceId": "who-eml",
"cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb",
"capturedAt": "2026-05-27",
"status": "stub"
},
{
"sourceId": "wsava-anesth",
"cid": "33d00d5e60cef25ef915e1a10bce437a52b208e15173796168c8d8868a2f1090",
"capturedAt": "2026-05-27",
"status": "stub"
}
],
"codes": {
"atc": {
"code": "N01AX03",
"name": "Ketamine",
"level": 5
},
"rxnorm": {
"cui": "6130",
"name": "Ketamine"
}
},
"drafting": {
"aiAssisted": false,
"aiModel": null,
"aiPromptHash": null,
"humanReviewer": "palmzamak2547",
"humanReviewedAt": "2026-05-27",
"humanEditsRatio": null
},
"signatures": [],
"reviewedBy": null,
"lastUpdated": "2026-05-27",
"version": 1,
"changelog": [
{
"version": 0,
"date": "2026-05-27",
"summary": "Seed entry — cross-checked from 5 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WHO Model List of Essential Medicines (22nd List, 2021), WSAVA Anaesthesia & Sedation guidelines). ATC N01AX03 + RxNorm 6130. Thai translation + faculty review pending."
},
{
"version": 1,
"date": "2026-05-27",
"summary": "Clinical content compiled from cited sources — ketamine 5–10 mg/kg IV with benzodiazepine co-induction verified against FDA Ketaset label + Lumb & Jones. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
}
]
}Public keys used
[]