Verify Isotretinoin

Drug JSON

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{
  "slug": "isotretinoin",
  "nameEn": "Isotretinoin",
  "nameTh": "ไอโซเทรทิโนอิน",
  "class": "Dermatology — systemic retinoid",
  "mechanism": "synthetic retinoid (vitamin A derivative) รุ่นแรก — ลดการทำงานและขนาดของต่อมไขมัน (sebostatic), ปรับการสร้างเคราตินและการอักเสบของผิวหนัง; ใช้กับโรคผิวหนังที่เกี่ยวกับต่อมไขมัน",
  "brandNamesTh": [
    "Accutane",
    "Roaccutane"
  ],
  "indications": [
    {
      "text": "sebaceous adenitis, sebaceous gland disorders, schnauzer comedo syndrome, บาง keratinization disorder ในสุนัข — ตอบสนอง ~50% ของ sebaceous adenitis",
      "cites": [
        "paper-isotretinoin",
        "merck-derm-vitamins"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ teratogenic รุนแรงมาก — ห้ามในสัตว์ตั้งท้อง + ผู้หญิงตั้งครรภ์/อาจตั้งครรภ์ห้ามสัมผัส; ⚠️ ตรวจค่าตับ + triglyceride ทุก 2 สัปดาห์ช่วง induction (ตับเป็นพิษ/ไขมันสูง); KCS (ตาแห้ง); ต้องใช้ ≥2 เดือนก่อนประเมินผล",
      "cites": [
        "paper-isotretinoin",
        "merck-derm-vitamins"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ตับเอนไซม์สูง, triglyceride สูง, KCS (ตาแห้ง), GI upset, ผิวแห้ง; ⚠️ teratogenic",
      "cites": [
        "paper-isotretinoin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Sebaceous adenitis / sebaceous gland disorders",
      "route": "PO",
      "dose": "1–3 mg/kg PO วันละครั้ง (หรือแบ่ง q12h) จนดีขึ้น แล้ว taper เป็นวันเว้นวัน/0.5 mg/kg; ใช้ ≥2 เดือน",
      "cites": [
        "paper-isotretinoin",
        "merck-derm-vitamins"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจค่าตับ + triglyceride ทุก 2 สัปดาห์ช่วง induction; Schirmer tear test (KCS); ยืนยันไม่ตั้งท้อง",
      "cites": [
        "paper-isotretinoin"
      ]
    }
  ],
  "citations": [
    {
      "id": "paper-isotretinoin",
      "type": "paper",
      "title": "Sebaceous adenitis in dogs treated with isotretinoin and etretinate: 30 cases (JAVMA 1995)",
      "url": "https://pubmed.ncbi.nlm.nih.gov/7601715/",
      "year": 2023,
      "note": "Peer-reviewed canine isotretinoin sebaceous adenitis study.",
      "cid": null
    },
    {
      "id": "merck-derm-vitamins",
      "type": "textbook",
      "title": "Vitamins and Minerals for Integumentary Disease in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-integumentary-system/vitamins-and-minerals-for-integumentary-disease-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-isotretinoin",
      "type": "monograph",
      "title": "Isotretinoin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Isotretinoin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "D10BA01",
      "name": "Isotretinoin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / EveryCat / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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