Verify Heparin (unfractionated)

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "heparin",
  "nameEn": "Heparin (unfractionated)",
  "nameTh": "เฮพาริน (ชนิดไม่แยกส่วน)",
  "class": "Hematology — anticoagulant (antithrombin potentiator)",
  "mechanism": "เร่งการทำงานของ antithrombin III หลายเท่า ยับยั้ง thrombin (IIa) และ factor Xa จึงป้องกันการเกิดลิ่มเลือด; unfractionated ออกฤทธิ์เร็ว ปรับขนาดด้วยการตรวจการแข็งตัว",
  "brandNamesTh": [
    "Heparin sodium"
  ],
  "indications": [
    {
      "text": "ป้องกัน/รักษาภาวะลิ่มเลือดอุดตัน (feline arterial thromboembolism, DIC, pulmonary thromboembolism, IMHA thromboprophylaxis) ในสุนัขและแมว",
      "cites": [
        "merck-anticoagulant-h",
        "acvim-curative"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ห้ามในภาวะเลือดออกหรือเสี่ยงเลือดออก; ต้อง monitor (aPTT หรือ anti-Xa); antidote = protamine sulfate; ไม่ให้ IM (hematoma)",
      "cites": [
        "merck-anticoagulant-h"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "เลือดออก (เด่นสุด), thrombocytopenia, hematoma จุดฉีด; ต้องเฝ้าระวัง coagulation",
      "cites": [
        "acvim-curative"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Thromboprophylaxis / treatment",
      "route": "SC",
      "dose": "100–300 IU/kg SC ทุก 6–8 ชั่วโมง แล้วปรับตาม aPTT/anti-Xa",
      "cites": [
        "merck-anticoagulant-h",
        "acvim-curative"
      ]
    },
    {
      "species": "feline",
      "indication": "Arterial thromboembolism (ATE)",
      "route": "SC",
      "dose": "250–300 IU/kg SC ทุก 6 ชั่วโมง แล้วปรับตามการตรวจการแข็งตัว",
      "cites": [
        "acvim-curative"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ aPTT (เป้าหมาย ~1.5–2 เท่าของ baseline) หรือ anti-Xa; เฝ้าระวังเลือดออก + เกล็ดเลือด",
      "cites": [
        "acvim-curative"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-anticoagulant-h",
      "type": "textbook",
      "title": "Anticoagulants — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/hemostatic-and-anticoagulant-drugs",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "acvim-curative",
      "type": "guideline",
      "title": "CURATIVE consensus on rational use of antithrombotics in veterinary critical care",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6498440/",
      "year": 2024,
      "note": "ACVIM/AAHA consensus or guideline.",
      "cid": null
    },
    {
      "id": "wikipedia-heparin",
      "type": "monograph",
      "title": "Heparin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Heparin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "B01AB01",
      "name": "Heparin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / EMA-FDA labels / VSSO / ACVIM-AAHA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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