Verify Gonadorelin (GnRH)

Drug JSON

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{
  "slug": "gonadorelin",
  "nameEn": "Gonadorelin (GnRH)",
  "nameTh": "โกนาโดเรลิน",
  "class": "Reproductive — gonadotropin-releasing hormone (GnRH)",
  "mechanism": "GnRH สังเคราะห์ (decapeptide เหมือนของธรรมชาติ) กระตุ้นต่อมใต้สมองส่วนหน้าให้หลั่ง LH และ FSH — ใช้ขนาดเดี่ยว/เป็นพัก ๆ (ต่างจาก deslorelin ที่กระตุ้นต่อเนื่องเพื่อกด)",
  "brandNamesTh": [
    "Factrel",
    "Cystorelin",
    "OvaCyst"
  ],
  "indications": [
    {
      "text": "รักษา ovarian follicular cyst (เด่นในโค), เหนี่ยวนำ/จับเวลา ovulation, ประเมินการทำงานของ pituitary-gonadal axis; ใช้ในสุนัข/แมวแบบ off-label สำหรับ cystic ovary และ ovulation timing",
      "cites": [
        "fda-factrel",
        "merck-repro-overview"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ผลขึ้นกับจังหวะการให้ (single vs pulsatile); ประสิทธิภาพในสัตว์เล็กผันแปร; ปลอดภัยสูง (สุนัขทน 72 mcg/kg/วัน IV 15 วันไม่มีผลเสีย)",
      "cites": [
        "fda-factrel"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ผลข้างเคียงน้อยมาก; อาจมีปฏิกิริยาบริเวณฉีดเล็กน้อย",
      "cites": [
        "fda-factrel"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Ovulation induction / cystic ovary",
      "route": "IM",
      "dose": "50–100 mcg/ตัว IM (off-label; ปรับตามขนาดตัวและข้อบ่งใช้)",
      "cites": [
        "merck-repro-overview",
        "fda-factrel"
      ]
    },
    {
      "species": "bovine",
      "indication": "Ovarian follicular cyst (labeled)",
      "route": "IM",
      "dose": "100 mcg/ตัว IM (Factrel — labeled สำหรับโค)",
      "cites": [
        "fda-factrel"
      ]
    }
  ],
  "citations": [
    {
      "id": "fda-factrel",
      "type": "package-insert",
      "title": "Factrel (gonadorelin) — Zoetis veterinary label",
      "year": 2025,
      "url": "https://www.drugs.com/vet/ovacyst-gonadorelin.html",
      "note": "FDA/EMA-approved veterinary product label. Public regulatory labeling.",
      "cid": null
    },
    {
      "id": "merck-repro-overview",
      "type": "textbook",
      "title": "Systemic Pharmacotherapeutics of the Reproductive System — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-reproductive-system/overview-of-systemic-pharmacotherapeutics-of-the-reproductive-system-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-gonadorelin",
      "type": "monograph",
      "title": "Gonadorelin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Gonadorelin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "H01CA01",
      "name": "Gonadorelin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / WSAVA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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