Verify Fluticasone propionate

Drug JSON

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{
  "slug": "fluticasone",
  "nameEn": "Fluticasone propionate",
  "nameTh": "ฟลูติคาโซน",
  "class": "Respiratory — inhaled corticosteroid (maintenance)",
  "mechanism": "inhaled corticosteroid ออกฤทธิ์ต้านการอักเสบเฉพาะที่ในทางเดินหายใจ ลดการอักเสบเรื้อรังของหลอดลม โดยมีผล systemic น้อย; เป็น maintenance ของโรคหืดแมว (ไม่ใช่ rescue)",
  "brandNamesTh": [
    "Flovent",
    "Flixotide"
  ],
  "indications": [
    {
      "text": "ควบคุมระยะยาว (maintenance) ของโรคหืดแมวและหลอดลมอักเสบเรื้อรัง — ลดการอักเสบ eosinophilic ในทางเดินหายใจ; ใช้คู่ albuterol (rescue)",
      "cites": [
        "tvp-fluticasone",
        "paper-fluticasone"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ไม่ใช่ยา rescue — ออกฤทธิ์ช้า 10–14 วัน จึงต้องให้ prednisolone กินคู่ช่วง 2–4 สัปดาห์แรกแล้วค่อยลด; ระวังการติดเชื้อราในช่องปาก (oral candidiasis) พบน้อย",
      "cites": [
        "tvp-fluticasone"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ผล systemic น้อยเมื่อสูดพ่น; อาจมี oral/laryngeal irritation; การกด HPA axis น้อยกว่า steroid กิน",
      "cites": [
        "paper-fluticasone"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "Asthma / chronic bronchitis (maintenance)",
      "route": "inhaled",
      "dose": "110 mcg สูดพ่น ทุก 12 ชั่วโมง ผ่าน spacer (AeroKat) — เคสไม่รุนแรง 44 mcg q12h ก็พอ; รุนแรง 220 mcg q12h",
      "notes": "หายใจผ่าน mask+spacer 7–10 วินาที; ให้ pred กินคู่ช่วงแรก",
      "cites": [
        "tvp-fluticasone",
        "paper-fluticasone"
      ]
    }
  ],
  "citations": [
    {
      "id": "tvp-fluticasone",
      "type": "guideline",
      "title": "Treatment of Feline Lower Airway Disease — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/respiratory-medicine/treatment-of-feline-lower-airway-disease/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "paper-fluticasone",
      "type": "paper",
      "title": "Effects of fluticasone propionate dosage in an experimental model of feline asthma",
      "url": "https://pubmed.ncbi.nlm.nih.gov/19647461/",
      "year": 2023,
      "note": "Peer-reviewed feline asthma fluticasone dose study.",
      "cid": null
    },
    {
      "id": "wikipedia-fluticasone_propionate",
      "type": "monograph",
      "title": "Fluticasone propionate — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Fluticasone_propionate",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "R03BA05",
      "name": "Fluticasone",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / ACVIM-AAHA / VIN / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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