Verify Fluoxetine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "fluoxetine",
  "nameEn": "Fluoxetine",
  "nameTh": "ฟลูออกซิทีน",
  "class": "Behavioral — selective serotonin reuptake inhibitor (SSRI)",
  "mechanism": "ยา SSRI ยับยั้งการเก็บกลับ serotonin เพิ่มระดับ serotonin ใน synapse; ใช้รักษาปัญหาพฤติกรรม ออกฤทธิ์เต็มที่ต้องใช้ 4–6 สัปดาห์",
  "brandNamesTh": [
    "Reconcile",
    "Prozac"
  ],
  "indications": [
    {
      "text": "รักษาปัญหาพฤติกรรม: separation anxiety (มีรูปแบบรับรอง FDA = Reconcile), compulsive disorder, urine marking, aggression; ใช้ร่วมกับ behavior modification",
      "cites": [
        "petplace-fluoxetine",
        "pubmed-fluoxetine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามใช้ร่วม MAOI/ยา serotonergic อื่น (เสี่ยง serotonin syndrome); ระวังในโรคลมชัก (ลด seizure threshold), ตับ/ไตบกพร่อง",
      "cites": [
        "petplace-fluoxetine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "เบื่ออาหาร (พบบ่อยช่วงแรก), ง่วงซึม/กระสับกระส่าย, GI upset; ออกฤทธิ์เต็มที่ช้า (4–6 สัปดาห์)",
      "cites": [
        "petplace-fluoxetine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Anxiety / compulsive disorder",
      "route": "PO",
      "dose": "1–2 mg/kg PO ทุก 24 ชั่วโมง",
      "cites": [
        "petplace-fluoxetine"
      ]
    },
    {
      "species": "feline",
      "indication": "Urine marking / anxiety",
      "route": "PO",
      "dose": "0.5–1.5 mg/kg PO ทุก 24 ชั่วโมง (≈ 2–5 mg/ตัว)",
      "cites": [
        "petplace-fluoxetine"
      ]
    }
  ],
  "citations": [
    {
      "id": "petplace-fluoxetine",
      "type": "monograph",
      "title": "Fluoxetine (Prozac/Reconcile) for Dogs and Cats — PetPlace",
      "year": 2025,
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/fluoxetine-prozac-reconcile-for-dogs-and-cats",
      "note": "Clinical drug-library reference — behavioral dosing.",
      "cid": null
    },
    {
      "id": "pubmed-fluoxetine",
      "type": "paper",
      "title": "Efficacy of fluoxetine for canine behavioral disorders",
      "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278467/",
      "year": 2024,
      "note": "Peer-reviewed behavioral efficacy study.",
      "cid": null
    },
    {
      "id": "wikipedia-Fluoxetine",
      "type": "monograph",
      "title": "Fluoxetine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Fluoxetine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N06AB03",
      "name": "Fluoxetine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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