Verify Fluconazole

Drug JSON

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{
  "slug": "fluconazole",
  "nameEn": "Fluconazole",
  "nameTh": "ฟลูโคนาโซล",
  "class": "Antifungal — triazole (good CNS/urine penetration)",
  "mechanism": "ยาต้านเชื้อรากลุ่ม triazole ยับยั้ง 14-α-demethylase ขัดขวางการสร้าง ergosterol; ละลายน้ำดี ซึมเข้า CNS, ตา และปัสสาวะได้ดี ยับยั้ง CYP ของ host น้อยกว่า ketoconazole",
  "brandNamesTh": [
    "Diflucan"
  ],
  "indications": [
    {
      "text": "การติดเชื้อรา โดยเฉพาะที่ระบบประสาทส่วนกลาง (cryptococcosis), ตา, และทางเดินปัสสาวะ เนื่องจากซึมเข้าได้ดี; candidiasis",
      "cites": [
        "merck-antifungal"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ปรับลดขนาดในไตบกพร่อง (ขับทางไต); ตรวจตับเมื่อใช้นาน; drug interaction น้อยกว่า ketoconazole แต่ยังมี",
      "cites": [
        "merck-antifungal"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "โดยรวมทนได้ดีกว่ากลุ่ม imidazole; อาจมี GI upset, เอนไซม์ตับสูงเล็กน้อย",
      "cites": [
        "merck-antifungal"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "CNS / ocular / urinary mycosis",
      "route": "PO",
      "dose": "5–10 mg/kg PO ทุก 24 ชั่วโมง",
      "cites": [
        "merck-antifungal"
      ]
    },
    {
      "species": "feline",
      "indication": "Cryptococcosis / mycosis",
      "route": "PO",
      "dose": "50 mg/ตัว PO ทุก 12–24 ชั่วโมง (≈ 10 mg/kg/วัน)",
      "cites": [
        "merck-antifungal"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-antifungal",
      "type": "textbook",
      "title": "Antifungal Agents — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antifungal-agents/antifungal-agents-introduction",
      "note": "Merck antifungal pharmacology — azole dosing + ketoconazole hepatotoxicity. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "dailymed-fluconazole",
      "type": "regulatory-database",
      "title": "Fluconazole — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=fluconazole",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "ee20bc31bc39e4e7815242eda141729dbb2fb1e887fa504aa7dda654442c918e"
    },
    {
      "id": "atc-J02AC01",
      "type": "guideline",
      "title": "ATC J02AC01 — Fluconazole",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=J02AC01&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "f6018d21e2c3b985b43f8725f9808e8901a2b29259556737cf77b952b552ff02"
    },
    {
      "id": "pubchem-fluconazole",
      "type": "monograph",
      "title": "Fluconazole — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Fluconazole",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "b9452c58c11a498579da6cb1460a39df13c64a9c758fe97030f173ab6a40879d"
    },
    {
      "id": "who-eml-22",
      "type": "guideline",
      "title": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "year": 2021,
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "note": "Cross-checked source: drug appears on WHO EML — WHO recognizes its place in basic healthcare.",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=fluconazole",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=J02AC01&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Fluconazole",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    },
    {
      "id": "who-eml",
      "name": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "asOfDate": "2026-05-27",
      "license": "CC BY-NC-SA 3.0 IGO"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "ee20bc31bc39e4e7815242eda141729dbb2fb1e887fa504aa7dda654442c918e",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "f6018d21e2c3b985b43f8725f9808e8901a2b29259556737cf77b952b552ff02",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "b9452c58c11a498579da6cb1460a39df13c64a9c758fe97030f173ab6a40879d",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "who-eml",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "J02AC01",
      "name": "Fluconazole",
      "level": 5
    },
    "rxnorm": {
      "cui": "4450",
      "name": "Fluconazole"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 4 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WHO Model List of Essential Medicines (22nd List, 2021)). ATC J02AC01 + RxNorm 4450. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — fluconazole 5–10 mg/kg with CNS/urinary penetration profile verified against Merck antifungal. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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