Verify Doxorubicin

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "doxorubicin",
  "nameEn": "Doxorubicin",
  "nameTh": "ด็อกโซรูบิซิน",
  "class": "Antineoplastic — anthracycline (⚠️ cardiotoxic, vesicant)",
  "mechanism": "ยาเคมีบำบัดกลุ่ม anthracycline แทรกตัวใน DNA (intercalation) + ยับยั้ง topoisomerase II + สร้าง free radical ทำลายเซลล์มะเร็ง; เป็นกระดูกสันหลังของหลายโปรโตคอล (CHOP lymphoma, sarcoma)",
  "brandNamesTh": [
    "Adriamycin"
  ],
  "indications": [
    {
      "text": "มะเร็งต่อมน้ำเหลือง (CHOP protocol), osteosarcoma, hemangiosarcoma, และ sarcoma หลายชนิดในสุนัขและแมว — ยาหลักทาง oncology",
      "cites": [
        "vsso-protocols",
        "vca-doxorubicin"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ cardiotoxic สะสม — ห้ามเกิน cumulative ~180–240 mg/m² (สุนัข) เสี่ยง dilated cardiomyopathy; ⚠️ vesicant รุนแรง — extravasation ทำให้เนื้อตาย; ห้ามในหัวใจล้มเหลว; ประเมินหัวใจ (echo) ก่อน/ระหว่าง",
      "cites": [
        "vsso-protocols",
        "vca-doxorubicin"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก, GI (อาเจียน ท้องเสีย), ⚠️ cardiotoxicity สะสม, tissue necrosis จาก extravasation, ปฏิกิริยาขณะให้ยา (histamine), ในแมวเสี่ยง nephrotoxicity",
      "cites": [
        "vca-doxorubicin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Lymphoma / sarcoma (specialist use)",
      "route": "IV",
      "dose": "30 mg/m² IV ทุก 2–3 สัปดาห์ (สุนัข > 15 kg); สุนัขเล็ก/แมว ใช้ 1 mg/kg เพื่อเลี่ยงพิษ — ⚠️ oncology only, ผ่านสาย IV ที่แน่นอน",
      "notes": "⚠️ cumulative cap 180–240 mg/m²; ตรวจ echo + CBC ก่อนทุกรอบ",
      "cites": [
        "vsso-protocols",
        "vca-doxorubicin"
      ]
    },
    {
      "species": "feline",
      "indication": "Lymphoma (specialist use)",
      "route": "IV",
      "dose": "1 mg/kg IV (หรือ 20–25 mg/m²) ทุก 3 สัปดาห์ — ⚠️ oncology only; เฝ้าระวังไต",
      "cites": [
        "vsso-protocols"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ echocardiogram ก่อนเริ่มและติดตาม (cardiotoxicity), CBC ก่อนทุกรอบ, ค่าไตในแมว; เฝ้าระวังจุดให้ยา (extravasation)",
      "cites": [
        "vca-doxorubicin"
      ]
    }
  ],
  "citations": [
    {
      "id": "vsso-protocols",
      "type": "guideline",
      "title": "Chemotherapy Protocols — Veterinary Society of Surgical Oncology",
      "url": "https://www.vsso.org/chemotherapy-protocols",
      "year": 2024,
      "note": "VSSO chemotherapy protocol reference. Authoritative veterinary oncology.",
      "cid": null
    },
    {
      "id": "vca-doxorubicin",
      "type": "monograph",
      "title": "Doxorubicin — VCA Animal Hospitals",
      "year": 2025,
      "url": "https://vcahospitals.com/know-your-pet/doxorubicin",
      "note": "Clinical drug-library reference.",
      "cid": null
    },
    {
      "id": "wikipedia-doxorubicin",
      "type": "monograph",
      "title": "Doxorubicin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Doxorubicin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01DB01",
      "name": "Doxorubicin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VCA / VSSO chemo protocols / FDA-EMA labels / Today's Vet Practice), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

[]