Verify Diphenhydramine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "diphenhydramine",
  "nameEn": "Diphenhydramine",
  "nameTh": "ไดเฟนไฮดรามีน",
  "class": "Antihistamine — first-generation H1 antagonist",
  "mechanism": "ยาต้านฮิสตามีน H1 รุ่นที่ 1 ปิดกั้น H1 receptor ลดอาการแพ้ ผ่าน blood-brain barrier ได้จึงทำให้ง่วง; มีฤทธิ์ต้านอาเจียน (ใช้กับเมารถ) และ anticholinergic",
  "brandNamesTh": [
    "Benadryl"
  ],
  "indications": [
    {
      "text": "อาการแพ้ (allergic reaction, urticaria), pretreatment ก่อนให้ยาที่กระตุ้น histamine release, และป้องกันเมารถ; ฤทธิ์ระงับแพ้ในผิวหนังมักไม่พอเดี่ยว",
      "cites": [
        "aaha-allergic-skin"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังในต้อหิน, ต่อมลูกหมากโต/ปัสสาวะคั่ง, โรคหัวใจ (ฤทธิ์ anticholinergic); ทำให้ง่วงและอาจ paradoxical excitement",
      "cites": [
        "aaha-allergic-skin"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ง่วงซึม, ปากแห้ง, ปัสสาวะคั่ง, บางครั้งกระตุ้น (excitement) โดยเฉพาะในแมว",
      "cites": [
        "aaha-allergic-skin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Allergy / premedication / motion sickness",
      "route": "PO",
      "dose": "2–4 mg/kg PO ทุก 8–12 ชั่วโมง",
      "cites": [
        "aaha-allergic-skin"
      ]
    },
    {
      "species": "feline",
      "indication": "Allergy",
      "route": "PO",
      "dose": "~2 mg/kg PO ทุก 12 ชั่วโมง",
      "cites": [
        "aaha-allergic-skin"
      ]
    }
  ],
  "citations": [
    {
      "id": "aaha-allergic-skin",
      "type": "guideline",
      "title": "Antihistamine dosing — AAHA / veterinary dermatology allergic skin disease guidance",
      "year": 2023,
      "url": "https://www.aaha.org/resources/2023-aaha-management-of-allergic-skin-diseases-in-dogs-and-cats-guidelines/",
      "note": "AAHA guideline tables — H1-antihistamine canine/feline dosing. Authoritative.",
      "cid": null
    },
    {
      "id": "dailymed-diphenhydramine",
      "type": "regulatory-database",
      "title": "Diphenhydramine — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=diphenhydramine",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "2c279fb5d0396ea66cc246c843ac6c5f782a3768ebf754aa22966a8111d8d1b4"
    },
    {
      "id": "atc-R06AA02",
      "type": "guideline",
      "title": "ATC R06AA02 — Diphenhydramine",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=R06AA02&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "1ffe52bbf8a86c1298462c7043635d7d0823ee298cdf85e0eb310da8d99b66e0"
    },
    {
      "id": "pubchem-diphenhydramine",
      "type": "monograph",
      "title": "Diphenhydramine — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Diphenhydramine",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "03ccef01e981b44770ccac4a2a1d46ef38fe5f29f788004c003b03a056919fe8"
    },
    {
      "id": "who-eml-22",
      "type": "guideline",
      "title": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "year": 2021,
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "note": "Cross-checked source: drug appears on WHO EML — WHO recognizes its place in basic healthcare.",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=diphenhydramine",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=R06AA02&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Diphenhydramine",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    },
    {
      "id": "who-eml",
      "name": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "asOfDate": "2026-05-27",
      "license": "CC BY-NC-SA 3.0 IGO"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "2c279fb5d0396ea66cc246c843ac6c5f782a3768ebf754aa22966a8111d8d1b4",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "1ffe52bbf8a86c1298462c7043635d7d0823ee298cdf85e0eb310da8d99b66e0",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "03ccef01e981b44770ccac4a2a1d46ef38fe5f29f788004c003b03a056919fe8",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "who-eml",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "R06AA02",
      "name": "Diphenhydramine",
      "level": 5
    },
    "rxnorm": {
      "cui": "3498",
      "name": "Diphenhydramine"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 4 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WHO Model List of Essential Medicines (22nd List, 2021)). ATC R06AA02 + RxNorm 3498. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — diphenhydramine 2–4 mg/kg verified against AAHA allergic-skin-disease guidance. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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