Verify Cisapride

Drug JSON

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{
  "slug": "cisapride",
  "nameEn": "Cisapride",
  "nameTh": "ซิซาไพรด์",
  "class": "GI prokinetic — 5-HT4 agonist (feline megacolon)",
  "mechanism": "ยา prokinetic กระตุ้น 5-HT4 receptor เพิ่มการหลั่ง acetylcholine ในลำไส้ ทำให้กระเพาะและลำไส้ (รวมลำไส้ใหญ่) บีบตัวมากขึ้น; ออกฤทธิ์ทั่วทางเดินอาหารมากกว่า metoclopramide",
  "brandNamesTh": [
    "Propulsid (compounded)"
  ],
  "indications": [
    {
      "text": "ภาวะลำไส้ใหญ่โป่งพอง/ท้องผูกเรื้อรังในแมว (megacolon, constipation) — เป็นยาหลัก; ภาวะกระเพาะบีบตัวช้า (gastric stasis), reflux; ถูกถอนจากตลาดคน ปัจจุบันได้จาก compounding pharmacy",
      "cites": [
        "merck-prokinetic",
        "petplace-cisapride"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามใช้เมื่อสงสัยลำไส้อุดตันหรือทะลุ (เพิ่มการบีบตัว); ในคนถูกถอนเพราะ QT prolongation/arrhythmia — ระวังในสัตว์ที่มีปัจจัยเสี่ยงหัวใจ; ให้ก่อนอาหาร",
      "cites": [
        "merck-prokinetic"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "อาเจียน ท้องเสีย ปวดท้อง (จากการบีบตัวมาก); arrhythmia พบน้อยในสัตว์แต่ระวังตามประวัติคน",
      "cites": [
        "petplace-cisapride"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "Megacolon / chronic constipation",
      "route": "PO",
      "dose": "0.5–1 mg/kg PO ทุก 8–12 ชั่วโมง ก่อนอาหาร",
      "cites": [
        "merck-prokinetic",
        "petplace-cisapride"
      ]
    },
    {
      "species": "canine",
      "indication": "Gastric stasis / motility disorder",
      "route": "PO",
      "dose": "0.5 mg/kg PO ทุก 8–12 ชั่วโมง ก่อนอาหาร",
      "cites": [
        "petplace-cisapride"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-prokinetic",
      "type": "textbook",
      "title": "Drugs Affecting GI Motility — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-digestive-system/drugs-affecting-gastrointestinal-motility-in-monogastric-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "petplace-cisapride",
      "type": "monograph",
      "title": "Cisapride for Cats and Dogs — PetPlace",
      "year": 2025,
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/cisapride-for-cats-and-dogs",
      "note": "Clinical drug-library reference.",
      "cid": null
    },
    {
      "id": "wikipedia-cisapride",
      "type": "monograph",
      "title": "Cisapride — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Cisapride",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A03FA02",
      "name": "Cisapride",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VCA / VSSO chemo protocols / FDA-EMA labels / Today's Vet Practice), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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