Verify Cimetidine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "cimetidine",
  "nameEn": "Cimetidine",
  "nameTh": "ไซเมทิดีน",
  "class": "GI — H2-receptor antagonist (1st generation)",
  "mechanism": "H2-receptor antagonist รุ่นแรก — ปิดกั้น histamine H2 ที่ parietal cell ลดการหลั่งกรด; ยับยั้ง CYP450 มากกว่า H2 blocker อื่น (drug interactions เด่น); มีฤทธิ์ immunomodulatory อ่อน ๆ ที่ใช้เสริมใน mast cell tumor",
  "brandNamesTh": [
    "Tagamet"
  ],
  "indications": [
    {
      "text": "ลดกรด (gastritis, แผล, reflux), เสริมใน mast cell tumor (ลด histamine effect); ⚠️ ถูกแทนที่ด้วย famotidine/PPI เป็นส่วนใหญ่ (cimetidine ออกฤทธิ์อ่อนกว่า + interactions เยอะ)",
      "cites": [
        "vca-cimetidine",
        "petplace-cimetidine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยับยั้ง CYP450 — เพิ่มระดับยาหลายชนิด (theophylline, lidocaine, metronidazole, beta-blocker ฯลฯ); ปรับในไตบกพร่อง; ค่อย ๆ ลด (rebound acid); ให้บ่อย (q6-8h) — famotidine สะดวกกว่า",
      "cites": [
        "vca-cimetidine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "โดยรวมทนได้ดี; drug interactions (CYP inhibition) เป็นปัญหาหลัก; ให้ IV เร็วอาจ bradycardia/hypotension",
      "cites": [
        "vca-cimetidine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Acid suppression",
      "route": "PO",
      "dose": "5–10 mg/kg PO/IV ทุก 6–8 ชั่วโมง",
      "cites": [
        "vca-cimetidine",
        "petplace-cimetidine"
      ]
    },
    {
      "species": "feline",
      "indication": "Acid suppression",
      "route": "PO",
      "dose": "2.5–5 mg/kg PO/IV ทุก 12 ชั่วโมง",
      "cites": [
        "vca-cimetidine"
      ]
    }
  ],
  "citations": [
    {
      "id": "vca-cimetidine",
      "type": "monograph",
      "title": "Cimetidine — VCA Animal Hospitals",
      "url": "https://vcahospitals.com/know-your-pet/cimetidine",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "petplace-cimetidine",
      "type": "monograph",
      "title": "Cimetidine HCl (Tagamet) for Dogs and Cats — PetPlace",
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/cimetidine-hcl-tagamet-for-dogs-and-cats",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-cimetidine",
      "type": "monograph",
      "title": "Cimetidine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Cimetidine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A02BA01",
      "name": "Cimetidine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VCA / Today's Vet Practice / PetPlace / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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