Verify Chlorambucil

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "chlorambucil",
  "nameEn": "Chlorambucil",
  "nameTh": "คลอแรมบูซิล",
  "class": "Antineoplastic / immunosuppressant — alkylating agent (nitrogen mustard)",
  "mechanism": "ยา alkylating กลุ่ม nitrogen mustard เชื่อมขวาง DNA ยับยั้งการแบ่งเซลล์; ออกฤทธิ์อ่อนโยนกว่า cyclophosphamide จึงเหมาะใช้ระยะยาวในแมว (IBD/lymphoma) และโรคภูมิคุ้มกัน",
  "brandNamesTh": [
    "Leukeran"
  ],
  "indications": [
    {
      "text": "มะเร็งต่อมน้ำเหลืองชนิด low-grade และ inflammatory bowel disease (IBD) ในแมว, chronic lymphocytic leukemia, และโรคภูมิคุ้มกันบางชนิด; ทนได้ดีในการใช้ระยะยาว",
      "cites": [
        "merck-onco",
        "petplace-chlorambucil"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยาเคมีบำบัด — จัดการด้วย PPE; กดไขกระดูก (ค่อยเป็นค่อยไป); ปรับลดในตับ/ไตบกพร่อง",
      "cites": [
        "merck-onco"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก (myelosuppression — ตรวจ CBC), GI upset; โดยรวมผลข้างเคียงน้อยกว่า alkylating agent อื่น",
      "cites": [
        "petplace-chlorambucil"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "Low-grade lymphoma / IBD (specialist use)",
      "route": "PO",
      "dose": "2 mg/ตัว PO วันเว้นวัน หรือ 15 mg/m² วันละครั้งนาน 4 วัน ทุก 3 สัปดาห์ — ⚠️ ภายใต้ oncology",
      "cites": [
        "merck-onco",
        "petplace-chlorambucil"
      ]
    },
    {
      "species": "canine",
      "indication": "Chronic leukemia / immune-mediated (specialist use)",
      "route": "PO",
      "dose": "0.1–0.2 mg/kg PO วันละครั้งหรือวันเว้นวัน — ยืนยันโปรโตคอลกับ oncologist",
      "cites": [
        "merck-onco"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC ก่อนทุกรอบ (nadir นับเม็ดเลือด); เฝ้าระวัง cytopenia",
      "cites": [
        "merck-onco"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-onco",
      "type": "textbook",
      "title": "Antineoplastic Agents — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antineoplastic-agents/antineoplastic-agents-introduction",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "petplace-chlorambucil",
      "type": "monograph",
      "title": "Chlorambucil (Leukeran) for Dogs and Cats — PetPlace",
      "year": 2025,
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/chlorambucil-leukeran-for-dogs-and-cats",
      "note": "Clinical drug-library reference.",
      "cid": null
    },
    {
      "id": "wikipedia-chlorambucil",
      "type": "monograph",
      "title": "Chlorambucil — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Chlorambucil",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01AA02",
      "name": "Chlorambucil",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VCA / VSSO chemo protocols / FDA-EMA labels / Today's Vet Practice), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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