Verify Carbimazole

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "carbimazole",
  "nameEn": "Carbimazole",
  "nameTh": "คาร์บิมาโซล",
  "class": "Endocrine — antithyroid (methimazole prodrug)",
  "mechanism": "prodrug ที่ถูกเปลี่ยนเป็น methimazole (thiamazole) ในร่างกาย ยับยั้ง thyroid peroxidase ลดการสร้างฮอร์โมนไทรอยด์; มีรูป controlled-release (Vidalta) ให้วันละครั้ง",
  "brandNamesTh": [
    "Vidalta",
    "Neo-Mercazole"
  ],
  "indications": [
    {
      "text": "ภาวะไทรอยด์เป็นพิษในแมว (feline hyperthyroidism) — ทั้งคุมอาการระยะยาวและเตรียมก่อนผ่าตัด/รังสีไอโอดีน; รูป controlled-release ให้วันละครั้ง",
      "cites": [
        "ema-vidalta",
        "everycat-carbimazole"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวัง hepatotoxicity และ blood dyscrasia (neutropenia/thrombocytopenia) — ตรวจ CBC + ตับ; ห้ามในตั้งท้อง/ให้นม; ขนาด >20 mg/วันใช้ด้วยความระวัง",
      "cites": [
        "ema-vidalta",
        "everycat-carbimazole"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "อาเจียน เบื่ออาหาร ซึม (ช่วงแรก), คันหน้า/excoriation, ตับเอนไซม์สูง, เม็ดเลือดผิดปกติ (พบน้อยกว่า methimazole บางรายงาน)",
      "cites": [
        "everycat-carbimazole"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "Hyperthyroidism (controlled-release, Vidalta)",
      "route": "PO",
      "dose": "เริ่ม 15 mg/ตัว PO วันละครั้ง (10 mg ถ้า T4 รวม 50–100 nmol/L); ปรับ 10–25 mg วันละครั้งตาม T4",
      "cites": [
        "ema-vidalta",
        "everycat-carbimazole"
      ]
    },
    {
      "species": "feline",
      "indication": "Hyperthyroidism (conventional)",
      "route": "PO",
      "dose": "5 mg/ตัว PO ทุก 8–12 ชั่วโมง (รูปธรรมดา)",
      "cites": [
        "everycat-carbimazole"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ total T4 + CBC + ค่าตับ + ไต (ก่อนเริ่ม และซ้ำ ~2–3 สัปดาห์ ปรับขนาด); เฝ้าระวัง azotemia ที่เผยหลังคุมไทรอยด์",
      "cites": [
        "everycat-carbimazole"
      ]
    }
  ],
  "citations": [
    {
      "id": "ema-vidalta",
      "type": "package-insert",
      "title": "Vidalta (controlled-release carbimazole) — EMA veterinary label / dosing",
      "year": 2025,
      "url": "https://www.vidalta.com/vidalta/dosage/",
      "note": "FDA/EMA-approved veterinary product label. Public regulatory labeling.",
      "cid": null
    },
    {
      "id": "everycat-carbimazole",
      "type": "guideline",
      "title": "Treatment of Feline Hyperthyroidism with Carbimazole — EveryCat Health Foundation",
      "url": "https://everycat.org/cat-health/treatment-of-feline-hyperthyroidism-with-carbimazole/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-carbimazole",
      "type": "monograph",
      "title": "Carbimazole — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Carbimazole",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "H03BB01",
      "name": "Carbimazole",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / EMA-FDA labels / VSSO / ACVIM-AAHA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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