Verify Benazepril

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "benazepril",
  "nameEn": "Benazepril",
  "nameTh": "เบนาซีปริล",
  "class": "ACE inhibitor — RAAS blockade",
  "mechanism": "ยับยั้ง angiotensin-converting enzyme (ACE) ลดการสร้าง angiotensin II จึงขยายหลอดเลือด ลด afterload/preload และลดการคั่งน้ำผ่านการลด aldosterone; เป็น prodrug เปลี่ยนเป็น benazeprilat",
  "brandNamesTh": [
    "Fortekor",
    "Lotensin"
  ],
  "indications": [
    {
      "text": "รักษา CHF (เป็น 1 ใน 4 ยาหลักร่วมกับ furosemide + pimobendan + spironolactone) และ proteinuric kidney disease; ลด proteinuria ในแมวโรคไตเรื้อรัง",
      "cites": [
        "acvim-dmvd",
        "tufts-cardiorush"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามใช้ในภาวะขาดน้ำ, ความดันต่ำ, ตีบของหลอดเลือดไตทั้งสองข้าง; ระวัง hyperkalemia เมื่อใช้ร่วม spironolactone; หลีกเลี่ยงในสัตว์ตั้งท้อง",
      "cites": [
        "tufts-cardiorush"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ความดันต่ำ, azotemia (ลดการกรองที่ไต), hyperkalemia; ตรวจค่าไตและ K+ หลังเริ่มยา",
      "cites": [
        "tufts-cardiorush"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "CHF / proteinuria",
      "route": "PO",
      "dose": "0.25–0.5 mg/kg PO ทุก 12–24 ชั่วโมง (ฉลาก EU 0.25–1.0 mg/kg q24h; ACVIM แนะนำ 0.5 mg/kg q12h)",
      "cites": [
        "acvim-dmvd",
        "tufts-cardiorush"
      ]
    },
    {
      "species": "feline",
      "indication": "CKD proteinuria / cardiac",
      "route": "PO",
      "dose": "0.5–1 mg/kg PO ทุก 24 ชั่วโมง",
      "cites": [
        "tufts-cardiorush"
      ]
    }
  ],
  "citations": [
    {
      "id": "tufts-cardiorush",
      "type": "guideline",
      "title": "Cardiology Drug Formulary — Tufts CardioRush",
      "year": 2024,
      "url": "https://sites.tufts.edu/cardiorush/cardiology-drug-formulary/",
      "note": "Tufts Cummings veterinary cardiology academic formulary. Authoritative reference for cardiac dosing.",
      "cid": null
    },
    {
      "id": "acvim-dmvd",
      "type": "guideline",
      "title": "ACVIM Consensus: diagnosis + treatment of myxomatous mitral valve disease in dogs",
      "year": 2019,
      "url": "https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.15488",
      "note": "ACVIM consensus (J Vet Intern Med) — CHF therapy quartet (furosemide + pimobendan + ACEi + spironolactone). Authoritative.",
      "cid": null
    },
    {
      "id": "dailymed-benazepril",
      "type": "regulatory-database",
      "title": "Benazepril — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=benazepril",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "27a903eead29f09c223b43d3338a97f22af067da43d62842eff865a7dece8b23"
    },
    {
      "id": "atc-C09AA07",
      "type": "guideline",
      "title": "ATC C09AA07 — Benazepril",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=C09AA07&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "72418619c3fa4466e397bf6abf1c55da00d45807a3e1763415ff2f73f3cd3d6b"
    },
    {
      "id": "pubchem-benazepril",
      "type": "monograph",
      "title": "Benazepril — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Benazepril",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "a629a3ae4a82765951b799503737aabf577bf8f871b58d7bdbfad06a93f6088f"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=benazepril",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=C09AA07&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Benazepril",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "27a903eead29f09c223b43d3338a97f22af067da43d62842eff865a7dece8b23",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "72418619c3fa4466e397bf6abf1c55da00d45807a3e1763415ff2f73f3cd3d6b",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "a629a3ae4a82765951b799503737aabf577bf8f871b58d7bdbfad06a93f6088f",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "C09AA07",
      "name": "Benazepril",
      "level": 5
    },
    "rxnorm": {
      "cui": "18867",
      "name": "Benazepril"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 3 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM)). ATC C09AA07 + RxNorm 18867. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — benazepril 0.25–0.5 mg/kg (ACVIM 0.5 mg/kg q12h) verified against Tufts CardioRush + ACVIM DMVD consensus. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจค่าไต (creatinine, BUN) และ K+ ก่อนและ 3–7 วันหลังเริ่มยาหรือปรับขนาด",
      "cites": [
        "tufts-cardiorush"
      ]
    }
  ]
}

Public keys used

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