Verify Amphotericin B

Drug JSON

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{
  "slug": "amphotericin-b",
  "nameEn": "Amphotericin B",
  "nameTh": "แอมโฟเทอริซิน บี",
  "class": "Antifungal — polyene (systemic mycoses)",
  "mechanism": "polyene จับ ergosterol ที่เยื่อหุ้มเซลล์เชื้อรา สร้างรูรั่วทำให้เซลล์ตาย; ออกฤทธิ์แรงต่อเชื้อราระบบ แต่เป็นพิษต่อไตสูง — รูป lipid ลดพิษไต",
  "brandNamesTh": [
    "Fungizone",
    "AmBisome (liposomal)"
  ],
  "indications": [
    {
      "text": "เชื้อราระบบรุนแรง (blastomycosis, histoplasmosis, cryptococcosis, coccidioidomycosis), leishmaniasis ในสุนัขและแมว — มักใช้เมื่อ azole ไม่พอ",
      "cites": [
        "merck-antifungal-i",
        "wikipedia-amphotericin_b"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ พิษไตสูง (nephrotoxic) — ต้องให้สารน้ำก่อน, monitor BUN/creatinine, หยุดเมื่อไตแย่; ห้ามในไตบกพร่อง; รูป lipid (AmBisome) พิษไตน้อยกว่าแต่ราคาสูง; ให้ IV ช้า ๆ",
      "cites": [
        "merck-antifungal-i"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "azotemia/ไตวาย (dose-limiting), ไข้-หนาวสั่นขณะให้, K+/Mg ต่ำ, ซีด, phlebitis; สะสมพิษไตตามขนาดรวม",
      "cites": [
        "merck-antifungal-i"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Systemic mycosis — specialist",
      "route": "IV",
      "dose": "0.25–0.5 mg/kg IV (ช้า/เจือจาง) วันเว้นวัน จนถึง cumulative dose เป้าหมาย — ⚠️ ให้สารน้ำร่วม + monitor ไต",
      "notes": "รูป lipid: 1–3 mg/kg",
      "cites": [
        "merck-antifungal-i"
      ]
    },
    {
      "species": "feline",
      "indication": "Cryptococcosis — specialist",
      "route": "IV",
      "dose": "0.25 mg/kg IV (ช้า) วันเว้นวัน — แมวไวต่อพิษไต, ใช้ขนาดต่ำ + monitor",
      "cites": [
        "merck-antifungal-i"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ BUN/creatinine + electrolyte (K+, Mg) ก่อนทุกครั้งที่ให้; หยุด/เลื่อนเมื่อ azotemia",
      "cites": [
        "merck-antifungal-i"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-antifungal-i",
      "type": "textbook",
      "title": "Antifungal Agents — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antifungal-agents/polyene-antifungals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-amphotericin_b",
      "type": "monograph",
      "title": "Amphotericin B — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Amphotericin_B",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J02AA01",
      "name": "Amphotericin B",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / ACVIM-AAHA / VIN / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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