Verify Amantadine

Drug JSON

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{
  "slug": "amantadine",
  "nameEn": "Amantadine",
  "nameTh": "อะแมนตาดีน",
  "class": "CNS — NMDA antagonist (chronic pain adjunct)",
  "mechanism": "NMDA receptor antagonist (กลไกคล้าย ketamine) — ลด central sensitization / \"wind-up\" ของความปวด จึงเป็นยาเสริมในความปวดเรื้อรังและ neuropathic; ต้องใช้ร่วมยาแก้ปวดจริง (NSAID/opioid/gabapentin)",
  "brandNamesTh": [
    "Symmetrel"
  ],
  "indications": [
    {
      "text": "ยาเสริม (adjunct) ในความปวดเรื้อรัง/neuropathic (osteoarthritis, มะเร็ง, ปวดที่ดื้อยา) ในสุนัขและแมว — ใช้ใน multimodal protocol คู่ NSAID/gabapentin",
      "cites": [
        "tvp-amantadine",
        "merck-pain-u"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "เป็น adjunct ไม่ใช่ยาแก้ปวดเดี่ยว (ต้องคู่ยาแก้ปวดจริง); ออกฤทธิ์ค่อยเป็นค่อยไป (1–3 สัปดาห์); ⚠️ พิษในแมวที่ 30 mg/kg, พฤติกรรมเปลี่ยนที่ 15 mg/kg; ห้ามใช้ร่วม serotonergic เกิน; ปรับในไตบกพร่อง (ขับทางไต)",
      "cites": [
        "tvp-amantadine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ซึมหรือกระสับกระส่าย, GI upset/อาเจียน (dopaminergic); ขนาดสูง — agitation, ataxia",
      "cites": [
        "tvp-amantadine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Chronic / neuropathic pain (adjunct)",
      "route": "PO",
      "dose": "3–5 mg/kg PO ทุก 12–24 ชั่วโมง (q12h preferred); ใช้ร่วมยาแก้ปวดหลัก",
      "cites": [
        "tvp-amantadine",
        "merck-pain-u"
      ]
    },
    {
      "species": "feline",
      "indication": "Chronic / neuropathic pain (adjunct)",
      "route": "PO",
      "dose": "3–5 mg/kg PO วันละครั้ง",
      "cites": [
        "tvp-amantadine"
      ]
    }
  ],
  "citations": [
    {
      "id": "tvp-amantadine",
      "type": "guideline",
      "title": "Gabapentin and Amantadine for Chronic Pain in Dogs and Cats — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/pain_management/gabapentin-and-amantadine-for-chronic-pain/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "merck-pain-u",
      "type": "textbook",
      "title": "Pain Management / Analgesic Pharmacology in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-nervous-system/analgesic-pharmacology-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-amantadine",
      "type": "monograph",
      "title": "Amantadine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Amantadine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N04BB01",
      "name": "Amantadine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VCA / Today's Vet Practice / PetPlace / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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