Verify Zonisamide

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "zonisamide",
  "nameEn": "Zonisamide",
  "nameTh": "โซนิซาไมด์",
  "class": "Anticonvulsant — sulfonamide-derivative AED",
  "mechanism": "ยากันชักอนุพันธ์ sulfonamide ออกฤทธิ์หลายกลไก (ปิด Na/Ca channel, เสริม GABA); ครึ่งชีวิตยาวกว่า levetiracetam จึงให้ q12h; ใช้เสริมหรือเดี่ยวในบางกรณี",
  "brandNamesTh": [
    "Zonegran"
  ],
  "indications": [
    {
      "text": "ยากันชักเสริมหรือเดี่ยวในสุนัขและแมว; ทางเลือกเมื่อ phenobarbital มีผลข้างเคียง",
      "cites": [
        "cb-zonisamide",
        "tvp-aed-b"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "เป็นอนุพันธ์ sulfonamide — ระวังในสัตว์ที่แพ้ sulfa; ปรับในตับ/ไตบกพร่อง; อาจเกิด KCS เช่นเดียวกับ sulfonamide อื่น",
      "cites": [
        "cb-zonisamide"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ง่วงซึม, เดินเซ, เบื่ออาหาร, อาเจียน; พบ hepatotoxicity และ renal tubular acidosis ได้น้อย",
      "cites": [
        "cb-zonisamide"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Anticonvulsant",
      "route": "PO",
      "dose": "5–10 mg/kg PO ทุก 12 ชั่วโมง",
      "cites": [
        "cb-zonisamide"
      ]
    },
    {
      "species": "feline",
      "indication": "Anticonvulsant",
      "route": "PO",
      "dose": "5 mg/kg PO ทุก 12 ชั่วโมง (หรือ 5–10 mg/kg q24h)",
      "cites": [
        "cb-zonisamide"
      ]
    }
  ],
  "citations": [
    {
      "id": "cb-zonisamide",
      "type": "guideline",
      "title": "Zonisamide for Seizure Control in Dogs & Cats — Clinician's Brief",
      "year": 2024,
      "url": "https://www.cliniciansbrief.com/article/zonisamide",
      "note": "Peer-reviewed clinical reference — dog 5–10 mg/kg q12h, cat 5 mg/kg q12h.",
      "cid": null
    },
    {
      "id": "tvp-aed-b",
      "type": "guideline",
      "title": "Antiseizure Medications for Dogs and Cats — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/pharmacology/antiseizure-medications-for-dogs-and-cats/",
      "year": 2024,
      "note": "Peer-reviewed veterinary clinical practice journal.",
      "cid": null
    },
    {
      "id": "wikipedia-Zonisamide",
      "type": "monograph",
      "title": "Zonisamide — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Zonisamide",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N03AX15",
      "name": "Zonisamide",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

[]