Verify Zidovudine (AZT)

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "zidovudine",
  "nameEn": "Zidovudine (AZT)",
  "nameTh": "ไซโดวูดีน (AZT)",
  "class": "Antiviral — nucleoside reverse transcriptase inhibitor (retrovirus)",
  "mechanism": "nucleoside reverse transcriptase inhibitor (NRTI) — ยับยั้ง reverse transcriptase ของ retrovirus หยุดการสร้าง viral DNA; ใช้กับ FIV/FeLV ในแมว",
  "brandNamesTh": [
    "Retrovir",
    "AZT"
  ],
  "indications": [
    {
      "text": "การติดเชื้อ retrovirus ในแมว — FIV (feline immunodeficiency virus) และ FeLV (feline leukemia virus) ที่มีอาการ — ช่วยปรับ immunologic status (เพิ่ม CD4/CD8) และลด antigenemia",
      "cites": [
        "paper-azt",
        "veteriankey-antiviral"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ กดไขกระดูก (non-regenerative anemia, neutropenia) — ตรวจ CBC สม่ำเสมอ หยุดถ้า PCV ตก; ระวังในแมวที่มี anemia อยู่แล้ว; ปรับในไต/ตับบกพร่อง",
      "cites": [
        "paper-azt",
        "veteriankey-antiviral"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "⚠️ anemia (dose-limiting — ตรวจ CBC), neutropenia, GI upset; เฝ้า PCV ใกล้ชิด",
      "cites": [
        "paper-azt"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "FIV / FeLV (symptomatic)",
      "route": "PO",
      "dose": "5 mg/kg PO ทุก 12 ชั่วโมง (หรือ SC) — ⚠️ ตรวจ CBC ทุก 1–2 สัปดาห์ช่วงแรก",
      "cites": [
        "paper-azt",
        "veteriankey-antiviral"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC (PCV/neutrophil) ทุก 1–2 สัปดาห์ช่วงแรก แล้วทุกเดือน; หยุดหากซีดลง",
      "cites": [
        "paper-azt"
      ]
    }
  ],
  "citations": [
    {
      "id": "paper-azt",
      "type": "paper",
      "title": "Use of AZT and PMEA in treatment of FIV/FeLV-seropositive cats with clinical symptoms",
      "url": "https://pubmed.ncbi.nlm.nih.gov/1363008/",
      "year": 2023,
      "note": "Peer-reviewed feline retrovirus AZT study.",
      "cid": null
    },
    {
      "id": "veteriankey-antiviral",
      "type": "guideline",
      "title": "Antiviral Therapy (zidovudine for FIV/FeLV) — Veterian Key",
      "url": "https://veteriankey.com/antiviral-therapy/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-zidovudine",
      "type": "monograph",
      "title": "Zidovudine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Zidovudine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J05AF01",
      "name": "Zidovudine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / EveryCat / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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