Verify Xylazine

Drug JSON

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{
  "slug": "xylazine",
  "nameEn": "Xylazine",
  "nameTh": "ไซลาซีน",
  "class": "Sedative — alpha-2 adrenergic agonist",
  "mechanism": "alpha-2 adrenergic agonist กระตุ้น central alpha-2 receptor ลดการปล่อย norepinephrine ให้ความสงบ คลายกล้ามเนื้อ และระงับปวดระยะสั้น; reversible ด้วย yohimbine/atipamezole",
  "brandNamesTh": [
    "Rompun"
  ],
  "indications": [
    {
      "text": "ความสงบและระงับปวดระยะสั้นสำหรับหัตถการ, premedication ก่อนวางยาสลบ, และเหนี่ยวนำการอาเจียนในแมว (เลิกนิยม) ในสุนัข แมว และสัตว์ใหญ่",
      "cites": [
        "merck-injectable-j",
        "petplace-xylazine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ กดหัวใจ-หายใจ, bradycardia + AV block, อาเจียน; ห้าม/ระวังในโรคหัวใจ ตับ ไต และสัตว์ตั้งท้อง; ⚠️ reversible ด้วย yohimbine/atipamezole; สัตว์ยัง \"ตอบสนอง\" (กัด/เตะ) ต่อเสียงดังแม้ดูสงบ",
      "cites": [
        "merck-injectable-j",
        "petplace-xylazine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "หัวใจเต้นช้า, ความดันสองระยะ (สูงแล้วต่ำ), กดการหายใจ, อาเจียน, น้ำตาลในเลือดสูงชั่วคราว, ปัสสาวะมาก",
      "cites": [
        "petplace-xylazine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Sedation / analgesia (short)",
      "route": "IM",
      "dose": "0.5–1 mg/kg IV หรือ 1–2 mg/kg IM/SC (มักใช้คู่ opioid/ketamine; reversal = yohimbine/atipamezole)",
      "cites": [
        "merck-injectable-j",
        "petplace-xylazine"
      ]
    },
    {
      "species": "feline",
      "indication": "Sedation",
      "route": "IM",
      "dose": "0.5–1.1 mg/kg IM/SC",
      "cites": [
        "petplace-xylazine"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-injectable-j",
      "type": "textbook",
      "title": "Injectable Anesthetics / Alpha-2 Agonists — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/anesthetics/injectable-anesthetics",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "petplace-xylazine",
      "type": "monograph",
      "title": "Xylazine (Rompun) for Dogs and Cats — PetPlace",
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/xylazine-rompun-for-dogs-and-cats",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-xylazine",
      "type": "monograph",
      "title": "Xylazine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Xylazine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "QN05CM92",
      "name": "Xylazine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / CURATIVE / Tufts CardioRush / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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