Verify Vincristine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "vincristine",
  "nameEn": "Vincristine",
  "nameTh": "วินคริสติน",
  "class": "Antineoplastic — vinca alkaloid (chemotherapy)",
  "mechanism": "จับ tubulin ยับยั้งการสร้าง mitotic spindle ทำให้เซลล์มะเร็งหยุดที่ metaphase และตาย; ยังกระตุ้นการปล่อยเกล็ดเลือดจากไขกระดูก (ใช้ใน ITP บางกรณี)",
  "brandNamesTh": [
    "Oncovin",
    "Vincasar"
  ],
  "indications": [
    {
      "text": "เคมีบำบัดมะเร็งต่อมน้ำเหลือง (lymphoma, โปรโตคอล CHOP), transmissible venereal tumor (TVT — ตอบสนองดีมาก), และกระตุ้นเกล็ดเลือดใน immune-mediated thrombocytopenia",
      "cites": [
        "merck-chemo",
        "tvp-chemo"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยาเคมีบำบัด — ต้องจัดการโดยผู้เชี่ยวชาญ oncology พร้อม PPE; ⚠️ vesicant รุนแรง การรั่วออกนอกหลอดเลือด (extravasation) ทำให้เนื้อตายรุนแรง; ระวังใน MDR1 (เพิ่มพิษ)",
      "cites": [
        "merck-chemo",
        "tvp-chemo"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก (ปานกลาง), GI (อาเจียน ท้องผูก/ileus), peripheral neuropathy, ⚠️ tissue necrosis รุนแรงจาก extravasation; สัตว์ MDR1 เสี่ยงพิษสูงขึ้น",
      "cites": [
        "merck-chemo"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Lymphoma / TVT (specialist use)",
      "route": "IV",
      "dose": "0.5–0.7 mg/m² IV (ตาม body surface area) — ⚠️ ให้โดย oncologist เท่านั้น ผ่านสาย IV ที่แน่นอน; ยืนยันโปรโตคอลและขนาดทุกครั้ง",
      "cites": [
        "merck-chemo",
        "tvp-chemo"
      ]
    },
    {
      "species": "feline",
      "indication": "Lymphoma (specialist use)",
      "route": "IV",
      "dose": "0.5–0.7 mg/m² IV — ⚠️ specialist oncology only",
      "cites": [
        "merck-chemo"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC ก่อนทุกครั้ง (nadir นับเม็ดเลือด), เฝ้าระวังจุดให้ยา (extravasation), อาการ ileus/neuropathy",
      "cites": [
        "merck-chemo"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-chemo",
      "type": "textbook",
      "title": "Antineoplastic Agents — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antineoplastic-agents/antineoplastic-agents-introduction",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "tvp-chemo",
      "type": "guideline",
      "title": "Chemotherapy in companion animals — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/oncology/",
      "year": 2024,
      "note": "Peer-reviewed veterinary clinical practice journal.",
      "cid": null
    },
    {
      "id": "wikipedia-Vincristine",
      "type": "monograph",
      "title": "Vincristine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Vincristine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01CA02",
      "name": "Vincristine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (RECOVER 2024 / BSAVA / Merck / AAHA / ACVIM / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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