Verify Vasopressin (argipressin)

Drug JSON

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{
  "slug": "vasopressin",
  "nameEn": "Vasopressin (argipressin)",
  "nameTh": "วาโซเพรสซิน (อาร์จิเพรสซิน)",
  "class": "Vasopressor — non-adrenergic V1 agonist / antidiuretic hormone",
  "mechanism": "กระตุ้น V1 receptor ที่กล้ามเนื้อเรียบหลอดเลือด ทำให้หลอดเลือดหดตัวโดยไม่พึ่ง adrenergic pathway (ยังออกฤทธิ์ได้แม้ในภาวะเลือดเป็นกรด) ใช้ใน CPR และช็อกที่ดื้อต่อ catecholamine",
  "brandNamesTh": [
    "Pitressin",
    "Vasostrict"
  ],
  "indications": [
    {
      "text": "หัวใจหยุดเต้น (CPR — เป็นทางเลือกหรือเสริม epinephrine) และภาวะ vasodilatory shock ที่ดื้อต่อ catecholamine",
      "cites": [
        "recover-2024",
        "merck-cv-pharm"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ใช้เป็น vasopressor เฉพาะในบริบทวิกฤติ (CPR / refractory shock) เท่านั้น ไม่ใช่ยาทางเลือกแรกนอกบริบทนี้",
      "cites": [
        "merck-cv-pharm",
        "dailymed-vasopressin"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "หลอดเลือดหดตัวมากเกินจนขาดเลือด (ผิวหนัง/อวัยวะภายใน), ลด cardiac output เมื่อขนาดสูง",
      "cites": [
        "merck-cv-pharm",
        "wikipedia-Vasopressin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "CPR (cardiac arrest)",
      "route": "IV",
      "dose": "0.8 U/kg IV/IO ครั้งเดียว (RECOVER) — ใช้แทนหรือเสริม epinephrine",
      "cites": [
        "recover-2024"
      ]
    },
    {
      "species": "canine",
      "indication": "Catecholamine-resistant vasodilatory shock",
      "route": "IV",
      "dose": "CRI 0.5–5 mU/kg/min (0.0005–0.005 U/kg/min) IV titrate ตาม MAP",
      "cites": [
        "merck-cv-pharm",
        "plumbs"
      ]
    },
    {
      "species": "feline",
      "indication": "CPR (cardiac arrest)",
      "route": "IV",
      "dose": "0.8 U/kg IV/IO ครั้งเดียว (RECOVER)",
      "cites": [
        "recover-2024"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-H01BA01",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Vasopressin (argipressin) (H01BA01)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=H01BA01&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-vasopressin",
      "type": "package-insert",
      "title": "Vasopressin — DailyMed (US FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=vasopressin",
      "note": "US FDA structured product label. Authoritative for mechanism, indications, contraindications.",
      "cid": null
    },
    {
      "id": "merck-cv-pharm",
      "type": "textbook",
      "title": "Systemic Pharmacotherapeutics of the Cardiovascular System — Merck Veterinary Manual",
      "year": 2026,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system",
      "note": "Merck (MSD) Veterinary Manual. Authoritative veterinary clinical reference.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Dose cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "recover-2024",
      "type": "guideline",
      "title": "RECOVER 2024 CPR Drug Dosing Charts (Reassessment Campaign on Veterinary Resuscitation)",
      "year": 2024,
      "url": "https://recoverinitiative.org/wp-content/uploads/2024/07/RECOVER-2024-Drug-Dosing-Charts-LBS.pdf",
      "note": "Consensus veterinary CPR dosing charts. Authoritative emergency reference.",
      "cid": null
    },
    {
      "id": "wikipedia-Vasopressin",
      "type": "monograph",
      "title": "Vasopressin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Vasopressin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "H01BA01",
      "name": "Vasopressin (argipressin)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Vet Manual / Plumb’s / RECOVER 2024 / WHO ATC / FDA label), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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