Verify Ursodiol (ursodeoxycholic acid)

Drug JSON

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{
  "slug": "ursodiol",
  "nameEn": "Ursodiol (ursodeoxycholic acid)",
  "nameTh": "เออร์โซไดออล",
  "class": "Hepatobiliary — hydrophilic bile acid (choleretic)",
  "mechanism": "กรดน้ำดีชนิดชอบน้ำ (hydrophilic) แทนที่กรดน้ำดีที่เป็นพิษต่อตับ ลดการอักเสบและ apoptosis ของเซลล์ตับ เพิ่มการไหลของน้ำดี (choleretic) และมีฤทธิ์ต้านอนุมูลอิสระ",
  "brandNamesTh": [
    "Actigall",
    "Ursodiol",
    "Urso"
  ],
  "indications": [
    {
      "text": "โรคตับและทางเดินน้ำดีที่มีภาวะคั่งน้ำดี (cholestatic liver disease, chronic hepatitis, cholangitis/cholangiohepatitis ในแมว, gallbladder mucocele adjunct) ในสุนัขและแมว",
      "cites": [
        "petmd-ursodiol",
        "vin-ursodiol"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ห้ามใช้เมื่อมีการอุดกั้นทางเดินน้ำดีสมบูรณ์ (complete biliary obstruction) — เพิ่มการไหลของน้ำดีต้านการอุดตันเป็นอันตราย; ระวังในตับวายรุนแรง",
      "cites": [
        "vin-ursodiol"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "โดยรวมทนได้ดี; อาจมีท้องเสีย; ให้พร้อมอาหาร",
      "cites": [
        "petmd-ursodiol"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Cholestatic liver disease",
      "route": "PO",
      "dose": "10–15 mg/kg PO วันละครั้ง (พร้อมอาหาร)",
      "cites": [
        "petmd-ursodiol",
        "vin-ursodiol"
      ]
    },
    {
      "species": "feline",
      "indication": "Cholangitis / cholestasis",
      "route": "PO",
      "dose": "10–15 mg/kg PO วันละครั้ง",
      "cites": [
        "petmd-ursodiol"
      ]
    }
  ],
  "citations": [
    {
      "id": "petmd-ursodiol",
      "type": "monograph",
      "title": "Ursodiol for Dogs and Cats — PetMD",
      "url": "https://www.petmd.com/pharmacy/ursodiol-dogs-cats",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "vin-ursodiol",
      "type": "guideline",
      "title": "Ursodiol — Veterinary Partner (VIN)",
      "url": "https://veterinarypartner.vin.com/doc/?id=4952062",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-ursodeoxycholic_acid",
      "type": "monograph",
      "title": "Ursodeoxycholic acid — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Ursodeoxycholic_acid",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A05AA02",
      "name": "Ursodeoxycholic acid (ursodiol)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VIN / PetPlace / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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