Verify Topiramate

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "topiramate",
  "nameEn": "Topiramate",
  "nameTh": "โทพิราเมต",
  "class": "Anticonvulsant — multi-mechanism (add-on)",
  "mechanism": "ยากันชักหลายกลไก — ปิดกั้น voltage-gated sodium channel, เสริม GABA, ยับยั้ง glutamate (AMPA/kainate) และ carbonic anhydrase อ่อน ๆ; ใช้เสริมในชักดื้อยา",
  "brandNamesTh": [
    "Topamax"
  ],
  "indications": [
    {
      "text": "การชักที่ดื้อยา (refractory idiopathic epilepsy) ในสุนัข — เป็นยาเสริม (add-on) เมื่อ phenobarbital/KBr/levetiracetam ไม่พอ; ทนได้ดี",
      "cites": [
        "tvp-epilepsy-n",
        "paper-topiramate"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามหยุดกะทันหัน (ชัก rebound — ค่อย ๆ ลด); ปรับในไตบกพร่อง (ขับทางไต); ระวังนิ่วไต/metabolic acidosis (ฤทธิ์ CAI อ่อน); ครึ่งชีวิตสั้นในสุนัขจึงต้องให้บ่อย",
      "cites": [
        "tvp-epilepsy-n",
        "paper-topiramate"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ง่วงซึม เดินเซ (ataxia) โดยเฉพาะช่วงแรก, เบื่ออาหาร/น้ำหนักลด; โดยรวมทนได้ดี",
      "cites": [
        "paper-topiramate"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Refractory epilepsy (add-on)",
      "route": "PO",
      "dose": "เริ่ม 2 mg/kg PO ทุก 12 ชั่วโมง แล้วค่อยเพิ่มเป็น 5–10 mg/kg ทุก 8–12 ชั่วโมง ตามการตอบสนอง",
      "cites": [
        "tvp-epilepsy-n",
        "paper-topiramate"
      ]
    }
  ],
  "citations": [
    {
      "id": "tvp-epilepsy-n",
      "type": "guideline",
      "title": "Treatment Plans for Routine and Refractory Canine Epilepsy — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/neurology/treatment-plans-for-routine-and-refractory-canine-epilepsy/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "paper-topiramate",
      "type": "paper",
      "title": "Topiramate as add-on for refractory canine idiopathic epilepsy",
      "url": "https://pubmed.ncbi.nlm.nih.gov/24032479/",
      "year": 2023,
      "note": "Peer-reviewed canine topiramate add-on study.",
      "cid": null
    },
    {
      "id": "wikipedia-topiramate",
      "type": "monograph",
      "title": "Topiramate — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Topiramate",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N03AX11",
      "name": "Topiramate",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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