Verify Ticarcillin-clavulanate

Drug JSON

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{
  "slug": "ticarcillin-clavulanate",
  "nameEn": "Ticarcillin-clavulanate",
  "nameTh": "ไทคาร์ซิลลิน-คลาวูลาเนต",
  "class": "Antibiotic — antipseudomonal penicillin + beta-lactamase inhibitor",
  "mechanism": "ticarcillin (extended-spectrum/antipseudomonal penicillin) + clavulanate (beta-lactamase inhibitor) ยับยั้งการสร้างผนังเซลล์ ครอบคลุม gram-negative กว้างรวม Pseudomonas",
  "brandNamesTh": [
    "Timentin"
  ],
  "indications": [
    {
      "text": "ติดเชื้อ gram-negative รุนแรงรวม Pseudomonas, sepsis, แผลติดเชื้อดื้อยาในสุนัขและแมว (รูปฉีด) — สงวนสำหรับเคสที่ต้องการ antipseudomonal",
      "cites": [
        "merck-penicillins-k2",
        "petplace-ticarcillin"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามในสัตว์แพ้ penicillin; ปริมาณโซเดียมสูง (ระวังในโรคหัวใจ/ไต); ปรับในไตบกพร่อง; ใช้อย่างสมเหตุผล (antipseudomonal สงวน)",
      "cites": [
        "merck-penicillins-k2"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "GI upset, แพ้ยา, โซเดียมเกิน, เปลี่ยน gut flora; ให้เร็วเกินอาจกระตุ้นการชัก (ขนาดสูง)",
      "cites": [
        "petplace-ticarcillin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Serious gram-negative / Pseudomonas",
      "route": "IV",
      "dose": "30–50 mg/kg IV ทุก 6–8 ชั่วโมง",
      "cites": [
        "merck-penicillins-k2",
        "petplace-ticarcillin"
      ]
    },
    {
      "species": "feline",
      "indication": "Serious gram-negative infection",
      "route": "IV",
      "dose": "30–50 mg/kg IV ทุก 6–8 ชั่วโมง",
      "cites": [
        "merck-penicillins-k2"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-penicillins-k2",
      "type": "textbook",
      "title": "Penicillins (extended-spectrum) — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antibacterial-agents/penicillins",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "petplace-ticarcillin",
      "type": "guideline",
      "title": "Ticarcillin-clavulanate (Timentin) veterinary dosing",
      "url": "https://www.merckvetmanual.com/pharmacology/antibacterial-agents/penicillins",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-ticarcillin/clavulanic_acid",
      "type": "monograph",
      "title": "Ticarcillin/clavulanic acid — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Ticarcillin/clavulanic_acid",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J01CR03",
      "name": "Ticarcillin and beta-lactamase inhibitor",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / FDA labels / dvm360 / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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