Verify Thiamine (vitamin B1)

Drug JSON

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{
  "slug": "thiamine",
  "nameEn": "Thiamine (vitamin B1)",
  "nameTh": "ไทอามีน (วิตามินบี 1)",
  "class": "Metabolic & nutritional — vitamin B1 supplement",
  "mechanism": "วิตามินบี 1 (thiamine) — coenzyme จำเป็นในเมแทบอลิซึมคาร์โบไฮเดรตและการทำงานของระบบประสาท; ทดแทนในภาวะขาด (พบบ่อยในแมวจากอาหารปลาดิบ/ที่มี thiaminase หรือผ่านความร้อน/ซัลไฟต์)",
  "brandNamesTh": [
    "Vitamin B1",
    "Thiamine HCl"
  ],
  "indications": [
    {
      "text": "ภาวะขาด thiamine (พบบ่อยในแมว — อาหารปลาดิบ/มี thiaminase, อาหารถนอมด้วยซัลเฟอร์ไดออกไซด์) แสดงอาการทางประสาท (ventroflexion คอ ชัก ataxia); เสริมในโรคตับ",
      "cites": [
        "vca-thiamine",
        "merck-thiamine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ขนาด >50 mg ทาง IV ให้ช้า ๆ (เสี่ยง anaphylaxis); ปลอดภัยสูงทาง SC/IM/PO; แก้สาเหตุพื้นฐาน (เปลี่ยนอาหาร)",
      "cites": [
        "vca-thiamine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ปลอดภัยมาก (ส่วนเกินขับทางปัสสาวะ); IV เร็วเสี่ยง anaphylaxis; ปฏิกิริยาบริเวณฉีดเล็กน้อย",
      "cites": [
        "vca-thiamine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "Thiamine deficiency",
      "route": "SC",
      "dose": "10–25 mg/ตัว IM/SC ทุก 12–24 ชั่วโมง จนอาการดีขึ้น แล้ว 10 mg/kg PO นาน 21 วัน",
      "cites": [
        "vca-thiamine",
        "merck-thiamine"
      ]
    },
    {
      "species": "canine",
      "indication": "Thiamine deficiency",
      "route": "SC",
      "dose": "50–250 mg/ตัว IM/SC/PO ทุก 12–24 ชั่วโมง จนอาการดีขึ้น",
      "cites": [
        "vca-thiamine"
      ]
    }
  ],
  "citations": [
    {
      "id": "vca-thiamine",
      "type": "monograph",
      "title": "Thiamine — VCA Animal Hospitals",
      "url": "https://vcahospitals.com/know-your-pet/thiamine",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "merck-thiamine",
      "type": "textbook",
      "title": "Nutritional Disorders / Thiamine Deficiency — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/nervous-system/diseases-of-the-spinal-column-and-cord/nutritional-disorders-of-the-spinal-column-and-cord-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-thiamine",
      "type": "monograph",
      "title": "Thiamine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Thiamine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A11DA01",
      "name": "Thiamine (vitamin B1)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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