Verify Terbinafine

Drug JSON

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{
  "slug": "terbinafine",
  "nameEn": "Terbinafine",
  "nameTh": "เทอร์บินาฟีน",
  "class": "Antifungal — allylamine (dermatophytosis)",
  "mechanism": "ยาต้านเชื้อรากลุ่ม allylamine ยับยั้ง squalene epoxidase ขัดขวางการสร้าง ergosterol ของเยื่อหุ้มเซลล์เชื้อรา; สะสมในผิวหนัง ขน และเล็บได้ดี จึงเหมาะกับ dermatophytosis",
  "brandNamesTh": [
    "Lamisil"
  ],
  "indications": [
    {
      "text": "รักษา dermatophytosis (เชื้อราที่ผิวหนัง/ขน เช่น Microsporum canis) ในสุนัขและแมว; ทางเลือก/เสริมกับ itraconazole; ใช้กับเชื้อราในระบบบางชนิด",
      "cites": [
        "merck-terbinafine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังในโรคตับ (ตรวจตับเมื่อใช้นาน); โดยรวมปลอดภัยกว่ากลุ่ม azole ในแง่ drug interaction",
      "cites": [
        "merck-terbinafine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "อาเจียน เบื่ออาหาร, เอนไซม์ตับสูงเป็นครั้งคราว, ผื่นที่หน้า (facial pruritus ในแมวบางตัว)",
      "cites": [
        "merck-terbinafine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Dermatophytosis",
      "route": "PO",
      "dose": "30–40 mg/kg PO วันละครั้ง",
      "cites": [
        "merck-terbinafine"
      ]
    },
    {
      "species": "feline",
      "indication": "Dermatophytosis",
      "route": "PO",
      "dose": "30–40 mg/kg PO วันละครั้ง (อาจให้แบบ pulse)",
      "cites": [
        "merck-terbinafine"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-terbinafine",
      "type": "textbook",
      "title": "Antifungal Agents — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antifungal-agents/antifungal-agents-introduction",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-Terbinafine",
      "type": "monograph",
      "title": "Terbinafine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Terbinafine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "D01BA02",
      "name": "Terbinafine",
      "level": 5
    },
    "rxnorm": {
      "cui": "10428",
      "name": "Terbinafine"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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