Verify Tepoxalin

Drug JSON

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{
  "slug": "tepoxalin",
  "nameEn": "Tepoxalin",
  "nameTh": "เทพอกซาลิน",
  "class": "NSAID — dual COX/5-LOX inhibitor",
  "mechanism": "NSAID ที่ยับยั้งทั้ง cyclooxygenase (COX) และ 5-lipoxygenase (5-LOX) จึงลดทั้ง prostaglandin และ leukotriene — กลไกคู่ที่ต่างจาก NSAID อื่น",
  "brandNamesTh": [
    "Zubrin"
  ],
  "indications": [
    {
      "text": "ปวดและอักเสบจากกระดูกและข้อ (osteoarthritis) ในสุนัข — กลไก dual COX/LOX (หมายเหตุ: รูป Zubrin เลิกผลิตในบางตลาด)",
      "cites": [
        "merck-nsaids-k",
        "paper-tepoxalin"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามใช้ร่วม NSAID/corticosteroid อื่น (แผล GI); ระวังในโรคไต/ตับ, ภาวะขาดน้ำ, GI ulcer; ตรวจไต/ตับก่อนและระหว่างใช้ระยะยาว",
      "cites": [
        "merck-nsaids-k"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "GI upset (อาเจียน ท้องเสีย แผล), พิษไต/ตับ (เช่นเดียวกับ NSAID อื่น)",
      "cites": [
        "merck-nsaids-k"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Osteoarthritis pain",
      "route": "PO",
      "dose": "10 mg/kg PO วันแรก (loading) แล้ว 10 mg/kg วันละครั้ง (maintenance)",
      "cites": [
        "merck-nsaids-k",
        "paper-tepoxalin"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจค่าไต/ตับก่อนและเป็นระยะเมื่อใช้นาน; เฝ้า GI signs",
      "cites": [
        "merck-nsaids-k"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-nsaids-k",
      "type": "textbook",
      "title": "Nonsteroidal Anti-inflammatory Drugs — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/anti-inflammatory-agents/nonsteroidal-anti-inflammatory-drugs",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "paper-tepoxalin",
      "type": "paper",
      "title": "Tepoxalin: a dual COX/LOX inhibitor NSAID in dogs",
      "url": "https://pubmed.ncbi.nlm.nih.gov/15500573/",
      "year": 2023,
      "note": "Peer-reviewed canine tepoxalin pharmacology.",
      "cid": null
    },
    {
      "id": "wikipedia-tepoxalin",
      "type": "monograph",
      "title": "Tepoxalin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Tepoxalin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "M01AB16",
      "name": "Tepoxalin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / FDA labels / dvm360 / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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