Verify Tacrolimus

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "tacrolimus",
  "nameEn": "Tacrolimus",
  "nameTh": "แทโครลิมัส",
  "class": "Immunomodulator — calcineurin inhibitor (topical)",
  "mechanism": "calcineurin inhibitor (เช่นเดียวกับ cyclosporine แต่แรงกว่า) ยับยั้งการกระตุ้น T-cell และการสร้าง IL-2; ใช้รูปทาเฉพาะที่เป็นหลักในสัตว์ (ตา/ผิวหนัง) เพื่อเลี่ยงพิษ systemic",
  "brandNamesTh": [
    "Protopic (ointment)",
    "Tacrolimus 0.02–0.1%"
  ],
  "indications": [
    {
      "text": "keratoconjunctivitis sicca (KCS/ตาแห้งภูมิคุ้มกัน — ทางเลือก/เสริม cyclosporine), perianal fistula (anal furunculosis), atopic/immune-mediated dermatitis เฉพาะที่ ในสุนัข",
      "cites": [
        "tvp-tacrolimus",
        "wikipedia-tacrolimus"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ใช้รูปทาเฉพาะที่ (systemic เป็นพิษ + แพง); สวมถุงมือเวลาทา; ระวังการติดเชื้อเฉพาะที่; หลีกเลี่ยงบริเวณแผลเปิดกว้าง",
      "cites": [
        "tvp-tacrolimus"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ระคายเคืองเฉพาะที่ (แดง/แสบช่วงแรก); ดูดซึม systemic น้อยเมื่อใช้ตามขนาดทา",
      "cites": [
        "tvp-tacrolimus"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Keratoconjunctivitis sicca (KCS)",
      "route": "topical",
      "dose": "tacrolimus 0.02–0.03% หยอดตา ทุก 12 ชั่วโมง",
      "cites": [
        "tvp-tacrolimus"
      ]
    },
    {
      "species": "canine",
      "indication": "Perianal fistula / localized dermatitis",
      "route": "topical",
      "dose": "ointment 0.1% ทาบริเวณรอยโรค ทุก 12–24 ชั่วโมง (สวมถุงมือ)",
      "cites": [
        "tvp-tacrolimus"
      ]
    }
  ],
  "citations": [
    {
      "id": "tvp-tacrolimus",
      "type": "guideline",
      "title": "Topical tacrolimus in veterinary ophthalmology and dermatology — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/ophthalmology/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-tacrolimus",
      "type": "monograph",
      "title": "Tacrolimus — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Tacrolimus",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L04AD02",
      "name": "Tacrolimus",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / ACVIM-AAHA / VIN / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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