Verify Sulfasalazine

Drug JSON

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{
  "slug": "sulfasalazine",
  "nameEn": "Sulfasalazine",
  "nameTh": "ซัลฟาซาลาซีน",
  "class": "Intestinal — aminosalicylate anti-inflammatory (colitis)",
  "mechanism": "prodrug: แบคทีเรียในลำไส้ใหญ่ตัดเป็น 5-aminosalicylic acid (5-ASA ต้านการอักเสบเฉพาะที่ลำไส้ใหญ่) + sulfapyridine; ลดการอักเสบใน large bowel colitis",
  "brandNamesTh": [
    "Azulfidine",
    "Salazopyrin"
  ],
  "indications": [
    {
      "text": "large bowel inflammatory bowel disease / lymphocytic-plasmacytic colitis ในสุนัข — เป็นยาที่สัตวแพทย์หลายคนเลือกเป็นอันดับแรกสำหรับ colitis",
      "cites": [
        "vca-sulfasalazine",
        "merck-colitis"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ใช้นานเสี่ยง keratoconjunctivitis sicca (KCS/ตาแห้ง — จาก sulfapyridine) ต้อง monitor tear production; ห้ามในสัตว์แพ้ sulfonamide; ระวังในแมว (ไวต่อ salicylate — ใช้ขนาดต่ำ/ระวังมาก); ค่อย ๆ ลดเมื่อตอบสนอง",
      "cites": [
        "vca-sulfasalazine",
        "merck-colitis"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "⚠️ KCS (ตาแห้ง — ตรวจ Schirmer เป็นระยะ), GI upset, แพ้ sulfa, blood dyscrasia (พบน้อย); แมวไวต่อ salicylate",
      "cites": [
        "vca-sulfasalazine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Large bowel colitis / IBD",
      "route": "PO",
      "dose": "10–25 mg/kg PO ทุก 8 ชั่วโมง นาน 4–6 สัปดาห์ แล้วค่อย ๆ ลด (สูงสุด ~1 g/ครั้ง)",
      "cites": [
        "vca-sulfasalazine",
        "merck-colitis"
      ]
    },
    {
      "species": "feline",
      "indication": "Colitis (extreme caution)",
      "route": "PO",
      "dose": "⚠️ 10–20 mg/kg PO วันละครั้ง — แมวไวต่อ salicylate ใช้ระวังมาก + monitor",
      "cites": [
        "vca-sulfasalazine"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ tear production (Schirmer) เป็นระยะ — เฝ้า KCS; CBC เมื่อใช้นาน",
      "cites": [
        "vca-sulfasalazine"
      ]
    }
  ],
  "citations": [
    {
      "id": "vca-sulfasalazine",
      "type": "monograph",
      "title": "Sulfasalazine — VCA Animal Hospitals",
      "url": "https://vcahospitals.com/know-your-pet/sulfasalazine",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "merck-colitis",
      "type": "textbook",
      "title": "Colitis in Small Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/digestive-system/diseases-of-the-large-intestine-in-small-animals/colitis-in-small-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-sulfasalazine",
      "type": "monograph",
      "title": "Sulfasalazine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Sulfasalazine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A07EC01",
      "name": "Sulfasalazine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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