Verify Succimer (DMSA)

Drug JSON

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{
  "slug": "succimer",
  "nameEn": "Succimer (DMSA)",
  "nameTh": "ซักซิเมอร์ (DMSA)",
  "class": "Antidote — heavy-metal chelator (oral)",
  "mechanism": "meso-2,3-dimercaptosuccinic acid (DMSA) — chelator ที่มีหมู่ thiol จับโลหะหนัก (ตะกั่ว สารหนู ปรอท) เกิดสารประกอบขับทางปัสสาวะ; กินได้และผลข้างเคียงน้อยกว่า Ca-EDTA",
  "brandNamesTh": [
    "Chemet"
  ],
  "indications": [
    {
      "text": "พิษตะกั่ว (lead poisoning) และโลหะหนักอื่น (สารหนู ปรอท) ในสุนัขและแมว — chelator แบบกินที่ลดระดับตะกั่วในเลือดได้ผล + ปลอดภัยกว่า Ca-EDTA",
      "cites": [
        "paper-succimer-dog",
        "merck-lead"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ต้องกำจัดแหล่งโลหะออกจากทางเดินอาหารก่อน (เช่นเอาวัตถุตะกั่วออก); ปรับในไตบกพร่อง; GI upset; ให้รูปเหน็บได้ถ้าอาเจียน; ไม่ใช้ป้องกัน (ใช้เมื่อมีพิษยืนยัน)",
      "cites": [
        "paper-succimer-dog",
        "merck-lead"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "GI upset (อาเจียน ท้องเสีย), กลิ่นกำมะถัน; ผลข้างเคียงน้อยกว่า Ca-EDTA",
      "cites": [
        "paper-succimer-dog"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Lead poisoning",
      "route": "PO",
      "dose": "10 mg/kg PO ทุก 8 ชั่วโมง นาน 10 วัน (ให้รูปเหน็บได้ถ้าอาเจียน)",
      "cites": [
        "paper-succimer-dog",
        "merck-lead"
      ]
    },
    {
      "species": "feline",
      "indication": "Lead poisoning",
      "route": "PO",
      "dose": "10 mg/kg PO ทุก 8 ชั่วโมง นาน 10 วัน",
      "cites": [
        "merck-lead"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจระดับตะกั่วในเลือดหลังคอร์ส; ยืนยันกำจัดแหล่งโลหะออกแล้ว",
      "cites": [
        "merck-lead"
      ]
    }
  ],
  "citations": [
    {
      "id": "paper-succimer-dog",
      "type": "paper",
      "title": "Use of oral succimer (DMSA) for treatment of lead poisoning in dogs (JAVMA)",
      "url": "https://pubmed.ncbi.nlm.nih.gov/8575967/",
      "year": 2023,
      "note": "Peer-reviewed canine succimer lead-poisoning study.",
      "cid": null
    },
    {
      "id": "merck-lead",
      "type": "textbook",
      "title": "Lead Poisoning in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/toxicology/lead-poisoning/lead-poisoning-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-dimercaptosuccinic_acid",
      "type": "monograph",
      "title": "Succimer (DMSA) — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Dimercaptosuccinic_acid",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "V03AB09",
      "name": "Succimer (dimercaptosuccinic acid)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / dvm360 / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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