Verify Sotalol

Drug JSON

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{
  "slug": "sotalol",
  "nameEn": "Sotalol",
  "nameTh": "โซตาลอล",
  "class": "Class III antiarrhythmic + non-selective beta blocker",
  "mechanism": "ยาต้านหัวใจเต้นผิดจังหวะ class III (ยืด repolarization โดยปิด K channel) ร่วมกับฤทธิ์ non-selective beta blocker (class II); ใช้คุม ventricular tachyarrhythmia",
  "brandNamesTh": [
    "Betapace",
    "Sotalex"
  ],
  "indications": [
    {
      "text": "คุม ventricular tachyarrhythmia ในสุนัข (เช่น Boxer ARVC, DCM) และ supraventricular arrhythmia บางชนิด",
      "cites": [
        "merck-antiarrhythmics",
        "tufts-cardiorush"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังใน CHF/DCM (ฤทธิ์ beta blocker กดการบีบหัวใจ — ใช้ขนาดต่ำสุด), bradyarrhythmia, AV block; เสี่ยง proarrhythmia (QT prolongation)",
      "cites": [
        "tufts-cardiorush"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "หัวใจเต้นช้า, ความดันต่ำ, อาจกระตุ้น arrhythmia ใหม่ (proarrhythmia); ระวังเมื่อใช้ร่วม mexiletine",
      "cites": [
        "merck-antiarrhythmics"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Ventricular tachyarrhythmia",
      "route": "PO",
      "dose": "1–2.5 mg/kg PO ทุก 12 ชั่วโมง (เริ่มขนาดต่ำใน CHF/DCM)",
      "cites": [
        "merck-antiarrhythmics",
        "tufts-cardiorush"
      ]
    },
    {
      "species": "feline",
      "indication": "Ventricular arrhythmia",
      "route": "PO",
      "dose": "1–2.5 mg/kg PO ทุก 12 ชั่วโมง",
      "cites": [
        "merck-antiarrhythmics"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-antiarrhythmics",
      "type": "textbook",
      "title": "Antiarrhythmics for Use in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.msdvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/antiarrhythmics-for-use-in-animals",
      "note": "Merck — beta-blocker, sotalol, Ca-channel-blocker dosing. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "tufts-cardiorush",
      "type": "guideline",
      "title": "Cardiology Drug Formulary — Tufts CardioRush",
      "year": 2024,
      "url": "https://sites.tufts.edu/cardiorush/cardiology-drug-formulary/",
      "note": "Tufts Cummings veterinary cardiology academic formulary. Authoritative reference for cardiac dosing.",
      "cid": null
    },
    {
      "id": "dailymed-sotalol",
      "type": "regulatory-database",
      "title": "Sotalol — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=sotalol",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "7af223b1afc5a7045c1a46bca7d556a84ba79aa21e3aaaf91cdae993447d7bba"
    },
    {
      "id": "atc-C07AA07",
      "type": "guideline",
      "title": "ATC C07AA07 — Sotalol",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=C07AA07&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "7adbc251c99ae86fabeb5a8e286fb1436a5b523341e8bf6298215929306e7906"
    },
    {
      "id": "pubchem-sotalol",
      "type": "monograph",
      "title": "Sotalol — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Sotalol",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "af93054a2e16047a5558c6009af537540401a8fb272728ecb219c87e3b62a562"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=sotalol",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=C07AA07&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Sotalol",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "7af223b1afc5a7045c1a46bca7d556a84ba79aa21e3aaaf91cdae993447d7bba",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "7adbc251c99ae86fabeb5a8e286fb1436a5b523341e8bf6298215929306e7906",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "af93054a2e16047a5558c6009af537540401a8fb272728ecb219c87e3b62a562",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "C07AA07",
      "name": "Sotalol",
      "level": 5
    },
    "rxnorm": {
      "cui": "9947",
      "name": "Sotalol"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 3 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM)). ATC C07AA07 + RxNorm 9947. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — sotalol 1–2.5 mg/kg q12h + proarrhythmia/CHF cautions verified against Merck antiarrhythmics + Tufts CardioRush. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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