Verify Silymarin (milk thistle / silibinin)

Drug JSON

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{
  "slug": "silymarin",
  "nameEn": "Silymarin (milk thistle / silibinin)",
  "nameTh": "ซิลิมาริน (มิลค์ทิสเซิล)",
  "class": "Hepatobiliary — antioxidant hepatoprotectant",
  "mechanism": "กลุ่ม flavonolignan จาก milk thistle (องค์ประกอบหลัก silybin/silibinin) — antioxidant กำจัดอนุมูลอิสระ, เสถียรเยื่อหุ้มเซลล์ตับ, กระตุ้นการสร้างโปรตีนซ่อมเซลล์ตับ; เป็น hepatoprotectant (ปกป้อง ไม่ใช่รักษาหาย)",
  "brandNamesTh": [
    "Marin",
    "Denamarin (คู่ SAMe)",
    "Legalon"
  ],
  "indications": [
    {
      "text": "ปกป้องตับในโรคตับเรื้อรัง, พิษตับ (เช่น Amanita mushroom, acetaminophen, aflatoxin), เสริมการรักษาโรคตับ ในสุนัขและแมว — มักผสม SAMe (Denamarin)",
      "cites": [
        "vetdrugs-silybin",
        "paper-silymarin"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "โดยรวมปลอดภัยมาก (supplement); ขนาดและ bioavailability ผันแปรตามผลิตภัณฑ์ (รูป silybin-phosphatidylcholine ดูดซึมดีกว่า); ไม่ใช่ยารักษาหายขาด — เสริมการดูแลตับ",
      "cites": [
        "vetdrugs-silybin"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ปลอดภัยมาก; GI upset เล็กน้อยพบได้น้อย",
      "cites": [
        "vetdrugs-silybin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Hepatoprotection / liver disease",
      "route": "PO",
      "dose": "20–50 mg/kg/วัน PO (silymarin มาตรฐาน) แบ่งให้ 1–2 ครั้ง; รูป Denamarin ตามฉลากน้ำหนักตัว",
      "cites": [
        "vetdrugs-silybin",
        "paper-silymarin"
      ]
    },
    {
      "species": "feline",
      "indication": "Hepatoprotection / liver disease",
      "route": "PO",
      "dose": "20–50 mg/kg/วัน PO; หรือ Denamarin ตามขนาดตัว",
      "cites": [
        "vetdrugs-silybin"
      ]
    }
  ],
  "citations": [
    {
      "id": "vetdrugs-silybin",
      "type": "guideline",
      "title": "Silybin (Milk thistle / silymarin) veterinary dosing — Vet Drugs List",
      "url": "https://www.vet-ebooks.com/vetdrugslist/silybin-milk-thistle-silibinin-silymarin/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "paper-silymarin",
      "type": "paper",
      "title": "Efficacy of silymarin in therapeutic management of dogs with liver disease",
      "url": "https://ijvph.org/wp-content/uploads/2024/01/Resrarch_7__1_6.pdf",
      "year": 2023,
      "note": "Peer-reviewed canine silymarin liver study.",
      "cid": null
    },
    {
      "id": "wikipedia-silibinin",
      "type": "monograph",
      "title": "Silibinin (silymarin) — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Silibinin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A05BA03",
      "name": "Silymarin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / EveryCat / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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